SYNTHESIS OF RADIOSENSITIZING AGENTS

本合同的目标是设计、综合和表征 新型和/或新型非硝基放射增敏剂。预计承包商将 开发筛选工作产生的线索(NCI合同 N01-CM-67868)，其评估化合物的辐射敏感性 活动。预计承包商将合成铅的类似物 并开发了关于这些化合物功效的体外和体内数据 作为辐射增敏剂的化合物。临床使用的新型放射增敏剂是 从这份合同中可以预料到。

The objectives of this contract are to design, synthesize and characterize new and/or novel non-nitro radiosensitizers. The contractor is expected to develop the leads which result from the screening effort (NCI contract N01-CM-67868), which evaluates compounds for their radiosensitivity activity. The contractor is expected to synthesize analogs of the lead compounds and develop in vitro and in vivo data on the efficacy of these compounds as radiosensitizers. New radiosensitizers for clinical use are expected from this contract.