PREPARATION OF CHEMICALS AND DRUGS FOR CLINICAL TRIALS

临床试验用化学品和药物的制备

• 批准号: 3614531
• 负责人: JACK L PARSONS
• 金额: $ 29.37万
• 依托单位: STARKS ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-09-30 至 1991-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3614531
• 关键词: antineoplastics; biological products; chemical synthesis; drug design /synthesis /production; drug metabolism; drug quality /standard

The project is for the preparation of known chemicals and bulk drugs which are needed by the Program for clinical use. The compounds selected for preparation are not readily available in the quality or quantities required from the original supplier or on the open market. This project is part of the DTP's program to procure bulk chemicals and drugs for the treatment of human cancer and the study of drug action. This project provides the means to obtain nearly any type of chemical compound and the ability to provide large quantities of very high purity drugs. Assignments of materials for preparation will originate with the Pharmaceutical Resources Branch, NCI and will involve a wide variety of chemical structures. Many of the preparations will involve multi-step sequences and all materials prepared will be fully characterized. Solubility and stability studies and cost data will be provided upon request.

该项目为已知化学品及原料药的制备， 该计划需要用于临床使用。 所选化合物用于 不易获得所需质量或数量的制剂 来自原始供应商或公开市场。 该项目是 DTP 采购用于治疗的散装化学品和药物的计划 人类癌症和药物作用的研究。 该项目提供了获取几乎任何类型化学品的方法 化合物以及提供大量极高纯度的能力 药物。 准备材料的分配将由 NCI 药物资源分部将涉及多种领域 化学结构。 许多准备工作将涉及多个步骤 序列和准备的所有材料将得到充分表征。 溶解度和稳定性研究以及成本数据将在 要求。