MED CORD CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

承包商应作为医疗协调中心 病毒激活输血研究。这项研究旨在确定 如果输血后HIV-1和巨细胞病毒被激活 艾滋病毒-1感染者感染巨细胞病毒(CMV)，从而对预后产生不利影响。 它还将评估捐赠者白细胞产生这种情况的作用。 通过检测过滤或过滤去除白细胞的效果来激活 通过伽马辐射消除它们的增殖能力。最后， 这项研究将检查供者淋巴细胞在术后的持久性 输血。

The contractor shall serve as the Medical Coordinating Center for the Viral Activation Transfusion Study. This study is designed to determine if transfusion is followed by activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affects prognosis. It will also evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion.