EPIDEMIOLOGIC STUDY OF HUMAN RETROVIRUSES IN BLOOD DONOR

本合同的目标如下：1)确定 首次献血者中逆转录病毒血清阳性的流行率；2) 重复献血者中逆转录病毒血清转换率的测定 作为感染发生率的衡量标准；3)确定感染的危险因素 抗体阳性献血者；4)通过以下方式描述献血者群体 地理位置、年龄、性别、种族/民族和捐赠史 对流行率、发病率和风险因素进行许可分析；5)确定 接受逆转录病毒阳性血液单位并进行临床和 对这些受者进行实验室随访以确定 这些药物通过输血的传播性；以及6)建立血液 长期保存研究标本的标本储存库 供将来检测的捐赠者和接受者。

The objectives of this contract are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood donor population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence, incidence, and risk factors; 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.