LABORATORY FOR THE PROPHYLACTIC PENICILLIN STUDY II

预防性青霉素研究实验室 II

• 批准号: 2313222
• 负责人: ANN B BJORNSON
• 金额: $ 15.94万
• 依托单位: JAMES N. GAMBLE INSTITUTE OF MEDICAL RES
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-15 至 1995-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2313222
• 关键词: Streptococcus pneumoniae; Streptococcus pneumoniae vaccine; antibacterial antibody; bacterial pneumonia; biomedical facility; child (0-11); drug resistance; enzyme linked immunosorbent assay; human subject; human therapy evaluation; penicillins; serology /serodiagnosis

The objectives of this contract are to 1) identify interference by penicillin prophylaxis on the acquisition of antibodies to S. pneumoniae; 2) assess the emergence of penicillin resistant S. pneumoniae; 3) upon cessation of penicillin prophylaxis, compare the incidence of documented bacterial infection in that patient population with children receiving penicillin; 4) to determine if continued penicillin prophylaxis beyond 5 years of age interferes with the serum antibody response to booster immunization with the pneumococcal vaccine or subsequent development of natural serum antibodies to S. pneumoniae; 5) to determine, in children with S. pneumoniae infection, if they had detectable serum antibody to the infecting serotype; and 6) to determine if patients who develop severe pneumococcal infection have lower serum antibody titers to S. pneumoniae before infection or respond suboptimally to the pneumococcal vaccine as compared to patients without infection.

本合同的目的是：1)识别干扰