PHYSIOLOGY OF BONE METABOLISM IN AN AGING POPULATION

老龄化人群骨代谢的生理学

• 批准号: 3090942
• 负责人: B. LAWRENCE RIGGS
• 金额: $ 96.23万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-09-01 至 1994-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3090942
• 关键词: aging; osteoporosis

Because of its high incidence and because of its devastating socioeconomic consequences, involutional osteoporosis is one of the most important disorders affecting the aging population. The disease causes 1.3 million fractures, including 240,000 hip fractures, each year. Almost one-third of women over age 65 years will have had vertebral fractures. The lifetime risk of hip fracture is 15% in women and 5% in men. Fifty percent of survivors cannot walk independently afterwards, and 25 to 50% are committed to long-term nursing home care. Overall costs of osteoporosis are estimated as $7 to $10 billion annually in the United States. In order to treat and to prevent this disorder we need 1) to know more about basic physiologic mechanisms regulating bone cell function, 2) to elucidate the mechanisms of disordered regulation of bone cell function in osteoporosis, 3) to define more sharply clinical risk factors for fractures, and 4) to find a safe and effective means of prevention that would be widely used by the general population of aging women. To accomplish these aims is our overall goal. The Program Project contains four independent research components and an administrative and biostatistical core. Project 1, "Pathophysiology of Osteoporosis," is the clinical investigation component. It tests the hypothesis that the disease results from impaired production of several systemic and local bone cell regulatory factors or from impaired response to them. We will search for abnormalities of systemic regulatory factors and, by testing cultured human bone cells, will assess possible local abnormalities of bone cell regulation for the first time in the study of osteoporosis. Project 2, "Record Studies of Hip Fractures" is the epidemiology component. It features a series of unique population-based retrospective (non-current, historical) cohort studies designed to determine the incidence of hip and various other age-related fractures and identify risk factors for them. In specified cohorts of patients with the risk factor, the incidence of fracture will be compared with the expected incidence rates in the community population. Project 3, "Regulation of Bone Cell Function," is the basic science component. It uses cell biology and molecular biology techniques to evaluate the effect and mechanism of action of sex steroids and growth factors on cultured normal human osteoblast-like cells. Project 4, "Preventive Therapy with Calcium," is the clinical trial component. It is designed to determine if bone loss in elderly women can be prevented or reduced by calcium supplementation as is suggested by our preliminary data.

因为它的高发病率和它的破坏性 社会经济后果，更年期骨质疏松症是最重要的 影响老龄化人口的重要疾病。 这种疾病会导致 1.3每年有240，000例骨折，其中包括240，000例髋部骨折。 几乎三分之一的65岁以上的女性会有脊椎 骨折 髋部骨折的终生风险在女性中为15%，在男性中为5%。 男人 50%的幸存者事后无法独立行走， 25%到50%的人致力于长期的疗养院护理。 整体 骨质疏松症的费用估计为每年70亿至100亿美元， 美国的 为了治疗和预防这种疾病，我们需要 1)了解调节骨细胞的基本生理机制 功能，2）阐明紊乱的调节机制， 骨质疏松症的骨细胞功能，3）更准确地定义临床 骨折的危险因素，以及4）寻找安全有效的方法， 预防，将广泛使用的一般人口老龄化 妇女 实现这些目标是我们的总体目标。 程序 该项目包括四个独立的研究组成部分和一个 行政和生物统计核心。 项目1，“糖尿病的病理生理学” 骨质疏松症”是临床研究的组成部分。 它考验着 这种疾病是由几种 全身和局部骨细胞调节因子或从受损 回应他们。 我们将寻找系统性的异常 通过测试培养的人类骨细胞， 评估骨细胞调节的可能局部异常， 这是骨质疏松症研究中的第一次。 项目2，“记录研究 髋关节骨折”是流行病学的组成部分。 它包括一系列 独特的基于人群的回顾性（非当前、历史）队列 研究旨在确定髋关节和各种其他 与年龄相关的骨折，并确定其风险因素。 在指定 队列患者的危险因素，骨折的发生率将 与预期的社区发病率进行比较 人口 项目3，“调节骨细胞功能”，是基本的 科学成分。 它利用细胞生物学和分子生物学 评估性作用效果和作用机制的技术 类固醇和生长因子对培养的正常人成骨细胞样细胞的影响 细胞 项目4，“钙的预防性治疗”，是临床 试用组件。 它的目的是确定老年人的骨质流失是否 妇女可以预防或减少钙补充剂， 根据我们的初步数据。