AGED-RELATED CHANGES IN THE LIMBIC SYSTEM OF THE PRIMATE BRAIN
灵长类大脑边缘系统与年龄相关的变化
基本信息
- 批准号:3802175
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Macaca mulatta acetylcholinesterase aging amygdala animal age group animal old age axon brain brain mapping cell death cell sorting choline cognition disorders cryostat dendrites electron microscopy ethology gamma aminobutyrate hippocampus histochemistry /cytochemistry innervation juvenile animal limbic system lipofuscin memory disorders mitochondria neuroanatomy neurochemistry neurons neuropil neurotransmitter receptor prosencephalon receptor binding stainings synapses temporal lobe /cortex
项目摘要
This project is a modification of Project 3 from the previous submission
which focuses on age-related changes in the morphological and neurochemical
state of the basal forebrain and temporal lobe limbic system of the primate
brain. The present project has been expanded to include additional
chemical neuroanatomical techniques to address age-related changes in cell
number, afferent innervation and, density of high affinity uptakes sites
and pre- and postsynaptic receptors of all of the major neurochemical
innervation rather than cell loss form the structural and chemical
substrates of age-related cognitive decline including memory impairment.
This hypothesis will be investigated by addressing the following specific
aims concerning age-related changes in the temporal lobe limbic system: (1)
to determine if there is a selective loss in intrinsic or extent of cell
death or shrinkage, (2) to determine if there is a selective loss in
intrinsic or extrinsic GABAergic neurons, (3) to determine if there are
alterations in the neuropil, (4) to determine whether there is a loss or
altered morphology of synapses, (5) to determine if there are alterations
in the density and distribution of high affinity neurotransmitter uptake
sites, (6) to determine whether there are alterations in the density and
distribution of pre- and postsynaptic receptors, (7) to determine whether
the time course and features of the loss of magnocellular neurons of the
basal forebrain. Furthermore, in collaboration with Projects 2 and 3,
another aim will be to determine the age-related changes in the density and
distribution of high affinity uptake sites and pre- and postsynaptic
receptors in the dorsolateral prefrontal association cortex, and in
collaboration with Project 5, to determine changes in these same
neurotransmitter levels. To accomplish these specific aims, a combination
of light and electronmicroscopic measures and state-of-the-art in vitro
ligand binding techniques will be utilized. In this way, within the same
animal the age-related structural and chemical neuroanatomical changes that
occur in the basal forebrain and temporal lobe limbic system can be
correlated with memory impairments and other cognitive dysfunctions.
这个项目是对之前提交的项目3的修改
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DOUGLAS L ROSENE其他文献
DOUGLAS L ROSENE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DOUGLAS L ROSENE', 18)}}的其他基金
BASAL FOREBRAIN AND LIMBIC SYSTEM IN AGING--A BEHAVIORAL AND ANATOMICAL STUDY (RH
衰老过程中的基底前脑和边缘系统——行为和解剖学研究(RH
- 批准号:
3817543 - 财政年份:
- 资助金额:
-- - 项目类别:
AGE-RELATED CHANGES IN THE LIMBIC SYSTEM OF THE PRIMATE BRAIN
灵长类大脑边缘系统与年龄相关的变化
- 批准号:
3745415 - 财政年份:
- 资助金额:
-- - 项目类别:
ANATOMICAL CHANGES IN THE HIPPOCAMPAL FORMATION WITH AGING
海马结构随衰老的解剖变化
- 批准号:
3823112 - 财政年份:
- 资助金额:
-- - 项目类别:
AGE-RELATED CHANGES IN THE LIMBIC SYSTEM OF THE PRIMATE BRAIN
灵长类大脑边缘系统与年龄相关的变化
- 批准号:
3789729 - 财政年份:
- 资助金额:
-- - 项目类别:
AGE-RELATED CHANGES IN THE LIMBIC SYSTEM OF THE PRIMATE BRAIN
灵长类大脑边缘系统与年龄相关的变化
- 批准号:
3767740 - 财政年份:
- 资助金额:
-- - 项目类别:
FETAL PROTEIN MALNUTRITION AND MENTAL RETARDATION--IMMUNOCYTOCHEMISTRY
胎儿蛋白营养不良与智力低下--免疫细胞化学
- 批准号:
3842863 - 财政年份:
- 资助金额:
-- - 项目类别:
相似海外基金
Effect of Acetylcholinesterase inhibitors on Bone Metabolism and Fracture Risk Factors among older adults with mild to moderate Alzheimer's Disease
乙酰胆碱酯酶抑制剂对患有轻至中度阿尔茨海默病的老年人骨代谢和骨折危险因素的影响
- 批准号:
10739853 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Acetylcholinesterase Complex Protein-Protein Interactions as Drug Targets Against Organophosphate-induced Neurotoxicity.
乙酰胆碱酯酶复合物蛋白质-蛋白质相互作用作为抗有机磷诱导的神经毒性的药物靶点。
- 批准号:
10772738 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Machine learning approaches to predict Acetylcholinesterase inhibition
预测乙酰胆碱酯酶抑制的机器学习方法
- 批准号:
10378934 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Acetylcholinesterase Complex Protein-Protein Interactions as Drug Targets Against Organophosphate-induced Neurotoxicity.
乙酰胆碱酯酶复合物蛋白质-蛋白质相互作用作为抗有机磷诱导的神经毒性的药物靶点。
- 批准号:
10303546 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Investigating the in vivo targets and mechanism of action of a toxic acetylcholinesterase-derived peptide upregulated in Alzheimer's disease
研究阿尔茨海默病中上调的有毒乙酰胆碱酯酶衍生肽的体内靶点和作用机制
- 批准号:
2480200 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Studentship
Improved Therapeutics for the Resurrection of the Aged Form of Acetylcholinesterase
老化乙酰胆碱酯酶复活的改进疗法
- 批准号:
9977281 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Improved Therapeutics for the Resurrection of the Aged Form of Acetylcholinesterase
老化乙酰胆碱酯酶复活的改进疗法
- 批准号:
10238898 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Elucidation of the cell protective mechanism of acetylcholinesterase variants in cardiomyocyte and approach to therapy for myocardial infarction
心肌细胞乙酰胆碱酯酶变异体的细胞保护机制的阐明及心肌梗死的治疗方法
- 批准号:
18K15850 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists
Effects of Alzheimer's disease drugs inhibiting acetylcholinesterase on prion replication.
阿尔茨海默病药物抑制乙酰胆碱酯酶对朊病毒复制的影响。
- 批准号:
481759-2015 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Reactivation of Aged Acetylcholinesterase: Design and Development of Novel Therap
老化乙酰胆碱酯酶的重新激活:新型疗法的设计和开发
- 批准号:
8735550 - 财政年份:2014
- 资助金额:
-- - 项目类别: