NEUROTOXICITY AND NEURODEGENERATION--BIOLOGICAL LINKS

神经元损伤的机制是由暴露于有毒物质引起的， 代理或神经退行性过程可能共享大量的 相似之处也有可能是环境毒物 在神经退行性疾病的发病机制中的作用。为这些 原因，科学家之间的相互作用， 神经毒理学和神经退行性疾病是至关重要的 重要性会议的总体目标是， 毒理学家，神经科学家和临床医生一起分析新的 关于神经毒性和神经变性过程的信息，并讨论 未来调查的共同领域。国会议尤其 将重点讨论三个相关主题。细胞因子的作用 介质/调节剂的神经元损伤将进行审查。 不同 神经毒性和神经退行性变的模型将被检查， 强调神经元死亡的可能共同途径。最后， 遗传和环境的相互作用将被确定为可能的 增加CNS对神经毒性的脆弱性的风险因素， 神经退行性疾病对这些问题的讨论有直接的 对我们理解中枢神经系统病理过程的意义 以及我们设计新的预防和治疗策略的能力 防止神经元损伤和退化。

The mechanisms of neuronal injury triggered by either exposure to toxic agents or neurodegenerative processes are likely to share substantial similarities. It is also possible that environmental toxicants may play a role in the pathogenesis of neurodegenerative disorders. For these reasons, interactions between scientists in the fields of neurotoxicology and neurodegenerative disorders are of critical importance. The general goal of the proposed conference is to bring together toxicologists, neuroscientists and clinicians to analyze new information on neurotoxic and neurodegenerative processes and to discuss common areas of future investigations. in particular, the conference will focus on three related topics. The role of cytokines as possible mediators/modulators of neuronal injury will be reviewed. Different models of neurotoxicity and neurodegeneration will then be examined with emphasis given to possible common pathways of neuronal death. Finally, genetic and environmental interactions will be identified as possible risk factors that enhance the vulnerability of the CNS to neurotoxic and neurodegenerative events. The discussion of these topics has direct implications for our understanding of pathologic processes in the CNS and our ability to design new preventive and therapeutical strategies against neuronal injury and degeneration.