NEUROTOXICITY AND NEURODEGENERATION--BIOLOGICAL LINKS

神经毒性和神经变性——生物学联系

• 批准号: 2552799
• 负责人: DONATO A DI MONTE
• 金额: $ 0.25万
• 依托单位: PARKINSON'S INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-24 至 1997-12-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2552799
• 关键词: meeting /conference /symposium; neural degeneration; neurotoxicology

The mechanisms of neuronal injury triggered by either exposure to toxic agents or neurodegenerative processes are likely to share substantial similarities. It is also possible that environmental toxicants may play a role in the pathogenesis of neurodegenerative disorders. For these reasons, interactions between scientists in the fields of neurotoxicology and neurodegenerative disorders are of critical importance. The general goal of the proposed conference is to bring together toxicologists, neuroscientists and clinicians to analyze new information on neurotoxic and neurodegenerative processes and to discuss common areas of future investigations. in particular, the conference will focus on three related topics. The role of cytokines as possible mediators/modulators of neuronal injury will be reviewed. Different models of neurotoxicity and neurodegeneration will then be examined with emphasis given to possible common pathways of neuronal death. Finally, genetic and environmental interactions will be identified as possible risk factors that enhance the vulnerability of the CNS to neurotoxic and neurodegenerative events. The discussion of these topics has direct implications for our understanding of pathologic processes in the CNS and our ability to design new preventive and therapeutical strategies against neuronal injury and degeneration.

接触有毒物质引发神经元损伤的机制 药物或神经退行性过程可能共享大量 相似之处。环境有毒物质也可能发挥作用 在神经退行性疾病的发病机制中发挥作用。对于这些 原因、各领域科学家之间的互动 神经毒理学和神经退行性疾病至关重要 重要性。拟议会议的总体目标是 毒理学家、神经科学家和临床医生一起分析新的 有关神经毒性和神经退行性过程的信息并进行讨论 未来调查的共同领域。特别是，会议 将重点关注三个相关主题。细胞因子的作用尽可能 将审查神经元损伤的介质/调节剂。 不同的 然后将检查神经毒性和神经变性模型 重点关注神经元死亡的可能常见途径。最后， 将尽可能确定遗传和环境的相互作用 增加中枢神经系统对神经毒性和神经毒性的脆弱性的危险因素 神经退行性事件。这些话题的讨论具有直接的意义 对我们理解中枢神经系统病理过程的影响 以及我们设计新的预防和治疗策略的能力 对抗神经元损伤和变性。