GORDON CONF ON MUSCLE EXCITATION/CONTRACTION COUPLING

描述（来自应用程序）： 这是一个帮助资助肌肉会议的建议： 兴奋-收缩（EC）耦合，定于1997年6月8日至12日，在 新罕布什尔州的科尔比索耶学院，由戈登赞助 研究会议。 EC耦合，转换动作的过程 肌细胞中增加[Ca 2 +]i和收缩的潜力，是 第一个公认的Ca 2+信号传导的例子。 最近的进展，使用不同的 技术，强调机制和分子的共同性， 在骨骼肌、心肌和平滑肌以及其他组织中Ca 2+信号传导中， 细胞的类型，兴奋的和非兴奋的。 新的可用染料和 共聚焦显微镜方法已经证明了局部 [Ca2+]肌肉功能的确定和控制的梯度， 神经元和非兴奋细胞。 将这些研究融合到 考虑到这一点，本次会议计划扩大 传统上专注于骨骼肌，并汇集了Ca 2+专家 其他组织中的信号。 会议将包括九个口头报告会议，加上 海报的连续展示。 第一次会议将制定 信号细胞器的结构和分子组成。 以下 其中两个将讨论决定离子稳态的过程，通常包括 发生的膜通道和泵ATP酶，以及改变， 体内平衡决定肌肉疲劳。 观察到的变化 遗传性突变的患者将从 疾病的观点，并作为了解正常角色的工具， 结构-功能关系。 EC偶联的主要分子， 电压传感器和Ca 2+释放通道，将是三个主题 会议，讨论结构-功能关系的研究，调制 离子、有机配体和其他蛋白质，以及 传感器和通道。 它们之间的相互作用以及在细胞中的功能 将在第七届会议上审议。 第8节比较最近 钙离子释放基本事件（火花和 最后一节课将考虑多样性、关系 两种主要的释放渠道之间的关系，以及它们的原因， 共处 戈登肌肉会议：EC耦合已定期举行， 三年，几十年。 最后一次会议是在1994年7月。 的 会议一直是唯一的讨论论坛， 传播这一领域的进展。 它有一个被证明的记录， 将来自世界各地的活跃调查人员聚集在一起， 鼓励自由交流想法和未发表的数据。 其组织 委员会有来自五大洲的代表，并将努力保持 1997年会议的出席情况在地域和年龄上都很均衡， 会议

DESCRIPTION (from the application): This is a proposal to help fund a Conference on Muscle: Excitation-Contraction (EC) Coupling, scheduled for June 8-12, 1997, at Colby Sawyer College, New Hampshire, under the sponsorship of Gordon Research Conferences. EC coupling, the process that translates the action potential in a muscle cell to increase in [Ca2+]i and contraction, is the first recognized example of Ca2+ signalling. Recent advances, using diverse techniques, underscore the commonality of mechanisms and molecules involved in Ca2+ signalling in skeletal, cardiac and smooth muscle, as well as other types of cells, excitable and nonexcitable. Newly available dyes and confocal microscopic approaches have demonstrated the importance of local [Ca2+] gradients in the determination and control of function in muscle, neurons and non excitable cells. Taking this confluence of studies into consideration, the present meeting has been planned to broaden the traditional focus on skeletal muscle, and bring together experts on Ca2+ signalling in other tissues. The conference will consist of nine oral presentation sessions, plus continuous showing of posters. The first session will develop the structural and molecular makeup of the signalling organelles. The following two will discuss processes determining ion homeostasis, including normally occurring membrane channels and pump ATPases, as well as the alterations in homeostasis that determine muscle fatigue. The alterations observed in patients with genetically transmitted mutations will be discussed from the standpoint of disease, and as tools to understand normal roles and structure-function relationships. The main molecules of EC coupling, the voltage sensor and the Ca2+ release channel, will be the topic of three sessions, discussing studies of structure-function relationship, modulation by ions, organic ligands and other proteins, and interactions between sensors and channels. Their interaction and the function at the cellular level will be considered in session 7. Session 8 will compare recent advances in determination of elementary events of Ca2+ release (sparks and related signals) and a final session will consider diversity, relationships between the two main classes of release channels, and reasons for their coexistence. The Gordon Conference on Muscle: EC coupling has been held regularly every three years for several decades. The last meeting was in July, 1994. The conference has consistently been the sole forum for discussion and dissemination of the advances in this field. It has a proven record of bringing together active investigators from all over the world, in a format that encourages free exchange of ideas and unpublished data. Its organizing committee has representatives from five continents, and will strive to keep a well balanced attendance, geographically and generationally, for its 1997 meeting.