US/JAPAN SEMINAR--BIOSYNTHESIS OF NATURAL PRODUCTS

美国/日本研讨会--天然产物的生物合成

• 批准号: 2012287
• 负责人: HEINZ G FLOSS
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2012287
• 关键词: biological products; biosynthesis; meeting /conference /symposium

DESCRIPTION (Applicant's Description) The 5th U.S.-Japan Seminar on the Biosynthesis of National Products will be jointly organized by Professors Heinz G. Floss, University of Washington, Seattle, Rodney B. Croteau and Norman G. Lewis, Washington State University, Pullman, in the US, and Professors Yutaka Ebizuka, Universiy of Tokyo, and Katsumi Kakinuma, Tokyo Insitute of Technology, in Japan. To be held on June 15-20, 1997 at Sun Mountain Lodge in Winthrop, State of Washington, it will bring together primarily academic participants and observers from the two counties, as well as a few leading researchers from Canada and two invited speakers from Europe. In addition to the well-established participants, it is planned to invite several junior scientists and newcomers to the field. These will be selected from a pool of candidates nominated by the core participants. A number of industrial researchers will also be invited, to provide an important link between basic science and practical applications emanating from it. The schedule will feature lectures in the morning and evening, with ample time in the afternoon for informal interactions between the participants to stimulate the creative exchange of ideas. Spectacular advances have been made in biosynthetic research since the last Seminar in 1994, and new directions are developing, especially in the translation of basic knowledge in the field of natural products biosynthesis into potential applications in the generation of new useful molecules or the commerical production of economically important compounds by bioprocesses. The emergence of experimental work in marine natural products biosynthesis and an increasing awareness of the ecological role of natural product biosythesis are other noteworthy developments. Many of these advances will be the subject of lectures and discussions at the 5th U.S.-Japan Binational Seminar, with its focus directed "Towards Engineering Biochemical Diversity". Diversity in natural product structure and function has, for many years, provided the wellspring of pharmaceutical discovery, a large fraction of the currently used clinical drugs being natural products or having been derived from natural products leads. A major objective of the meeting is to assess the current knowledge of biosynthetic pathways and the molecular origins of their diversity, and to explore how this knowledge can be utilized in applications of "combinatorial biochemistry" to the discovery and/or production of new pharmaceuticals. This is a subject of high interest to many institutes of the NIH, particularly the National Cancer Institute, which recently explored these issues in a special workshop.

描述（申请人的描述）第五届美国-日本讨论会 生物合成国货将由教授联合举办 海因茨G.弗洛斯，华盛顿大学，西雅图，罗德尼B。克罗托和 诺曼·G美国普尔曼华盛顿州立大学的刘易斯， 东京大学Yutaka Ebizuka教授和东京Katsumi Kakinuma教授 技术研究所，在日本。 定于1997年6月15日至20日 位于华盛顿州温斯洛普的山间小屋，它将汇集 主要是来自两个县的学术参与者和观察员，以及 作为来自加拿大的几位主要研究人员和来自 欧洲 除了已确定的参与者外，计划 邀请几位年轻的科学家和该领域的新人。 这些将是 从核心参与者提名的候选人中选出。 一 还将邀请一些工业研究人员， 基础科学和实际应用之间重要联系 从它。时间表将在上午和晚上的讲座， 下午有充足的时间进行非正式互动， 鼓励参与者进行创造性的思想交流。 壮观 自上一次研讨会以来，生物合成研究取得了进展。 1994年，新的方向正在发展，特别是在翻译 天然产物生物合成领域的基础知识转化为潜力 在产生新的有用分子或药物中的应用 通过生物过程生产经济上重要的化合物。 的 海洋天然产物生物合成实验工作的出现， 人们对天然产品的生态作用的认识日益提高 生物合成是其他值得注意的发展。 其中许多进展将 成为第五届美国-日本两国国家队 研讨会，其重点是“走向工程生化 多样性”。 天然产物结构和功能的多样性， 多年来，提供了药物发现的源泉，一个大的 目前使用的临床药物的一部分是天然产品，或 从天然产物中提取的铅。 的一个主要目标 会议的目的是评估生物合成途径的现有知识， 它们多样性的分子起源，并探索这些知识如何能够 在“组合生物化学”的应用中， 和/或新药物的生产。 这是一个很高的主题。 NIH的许多研究所，特别是国家癌症研究所， 该研究所最近在一个特别讲习班上探讨了这些问题。

项目成果

Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.

人类 Bub1：一种假定的纺锤体检查点激酶，与细胞增殖密切相关。

• 发表时间: 1998
• 期刊: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
• 作者: Ouyang,B;Lan,Z;Meadows,J;Pan,H;Fukasawa,K;Li,W;Dai,W
• 通讯作者: Dai,W

BUBR1 phosphorylation is regulated during mitotic checkpoint activation.

• 发表时间: 1999-11
• 期刊: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
• 作者: Wenqing Li;Zhengdao Lan;Huiyun Wu;Shechao Wu;J. Meadows;Jie Chen;Veronica Zhu;Wei Dai