CONFERENCE ON HEMATOPOIESIS

描述（申请人的描述）最令人兴奋的当前研究， 造血涉及干细胞分离、表征和临床应用。 应用和造血激素的分子生理学。 造血激素、其受体、受体拮抗剂和可溶性 受体在宿主防御中起着至关重要的作用， 治疗已成为最重要的生物学和临床课题之一， 在过去的二十年里 最近的重要进展包括分离出 血小板生成素与新造血干细胞的发现和应用 激素和宿主防御调节剂。 我们对干细胞的理解 造血干细胞是造血干细胞的一个重要组成部分。 在肿瘤疾病的新的和创造性的治疗中起着核心作用， 用于遗传和某些后天性疾病的基因治疗。 的 正常人和肿瘤患者造血素信号通路的特征 细胞和治疗干预的新靶点的定义是 关键问题。 会议的目标将是解决主要的 上述关于正常和肿瘤性造血的问题， 宿主防御 总体目标是综合专业信息 并定义了该领域的最新技术水平。 该计划将带来 将世界各地的专家聚集在一起，制定一个互动的议程， 环境建立科学家，研究生和博士后 伙计们

DESCRIPTION (Applicant's Description) The most exciting current research in hematopoiesis involves stem cell isolation, characterization, and clinical application, and the molecular physiology of the hematopoietic hormones. Hematopoietic hormones, their receptors, receptor antagonists, and soluble receptors play a crucial role in host defense, and their use in clinical therapy has become one of the most important biologic and clinical topics of the last two decades. Important recent advances include the isolation of thrombopoietin and the discovery and application of new hematopoietic hormones and host defense modulatotors. Our understanding of stem cell physiology is still rudimentary but the hematopoietic stem cell plays a central role in new and creative therapies for neoplastic disease as well as for gene therapy of genetic and certain acquired disorders. The characterization of hemopoietin-signaling pathways in normal and neoplastic cells and the definition of new targets for therapeutic intervention are critical issues. The goal of the conference will be to address the major questions outlined above regarding normal and neoplastic hematopoiesis and host defense. The overall aim is to synthesize the specialized information and define the state of the art in the field. The program will bring together world experts with an assigned agenda and establish an interactive environment for established scientists, graduate students, and postdoctoral fellows.