CONFERENCE ON LIPID MEDIATORS

描述(改编自申请者摘要)：申请支持 关于分子生物学最新进展的多学科会议， 脂类介体的调节和药理学将在Keystone举行， 科罗拉多州，1997年1月24日至30日。脂质调节剂是一个不同的家族 越来越多的分子被认为在正常生活中发挥着重要作用 生理学和病理生理学一样。黄曲霉毒素的最新研究进展 调节前列腺素、白三烯、血栓烷的合成， 和血小板激活因子揭示了意想不到的多种机制， 包括一个新的PGH合成酶基因的表达，参与了 核膜在白素生物合成中的作用及PAF的重要性 乙酰水解酶在调节炎症中的作用。此外，非酶 基于自由基生物化学的机制已被发现产生 二十碳二烯的同分异构体分子(前列腺素和白三烯) 它们具有很强的生物活性，可以作为新的血脂标志物 过氧化。新的氧化磷脂也被发现是 PAF受体激动剂。这次会议的目标是使 共同参与脂类介体研究的领先研究人员 更好地理解脂质介体的生物合成、调节和 控制权可能会浮现。 在过去的二十年里，冬季前列腺素会议一直在举行 几乎每年，作为感兴趣的调查人员的论坛 二十烷类化合物交流信息和讨论最新进展。这个 这次会议的非正式性质最大限度地促进了与会者之间的互动， 包括研究生、博士后研究员、大学调查人员 以及来自制药行业的人。尽管重要的是 在过去几年中取得的进展，带来的大多数会议 直接或间接参与脂质介体的科学家们共同拥有 去过海外。这限制了美国许多调查人员的接触 请各国参加，特别是学生和博士后研究员。 这次会议的主要目标是重新召开这次会议，以刺激 进一步发展这一领域，并鼓励学生和博士后 参与脂质介体基础研究。

DESCRIPTION (Adapted from Applicant's Abstract): Support is requested for a multidisciplinary conference covering recent advances in molecular biology, regulation, and pharmacology of lipid mediators to be held in Keystone, Colorado, january 24-30, 1997. Lipid mediators are a diverse family of molecules increasingly recognized as playing an important role in normal physiology as well as pathophysiology. Recent advances in studies of the regulation of the synthesis of prostaglandins, leukotrienes, thromboxanes, and platelet activating factor have revealed unexpected diverse mechanisms, including expression of a novel gene for PGH synthase, involvement of the nuclear envelope in leukotrience biosynthesis, and the importance of PAF acetyl hydrolase in regulating inflammation. In addition, nonenzymatic mechanisms based upon free radical biochemistry have been found to generate molecules isomeric to eicosanoids (both prostaglandins and leukotrienes) which have potent biological activity and serve as novel markers of lipid peroxidation. Novel oxidized phospholipids have also been found to be agonists for the PAF receptor. The goal of this meeting is to bring together the leading investigators involved in lipid mediator research so that a better understanding of lipid mediator biosynthesis, regulation, and control can emerge. For the past two decades a Winter Prostaglandin Conference had been held almost every year, serving as a forum for investigators interested in eicosanoids to exchange information and discuss recent advances. The informal nature of this meeting maximized interaction between participants, including graduate students, postdoctoral fellows, university investigators as well as those from the pharmaceutical industry. In spite of significant advances made within the past few years, most of the meetings which bring together scientists directly or indirectly involved in lipid mediators, have been overseas. This has limited access for many investigators in the United States to participate, and in particular students and postdoctoral fellows. This conference has a major goal to reinstitute this meeting, to stimulate further development in this area, and to encourage student and postdoctoral participation in lipid mediator basic research.