VASCULAR RELATIONS OF BLOOD CELLS AND PROTEINS

本研究的目的是研究正常人的血液流变学和血流动力学 病理模型是一项跨学科的协作工作，旨在 表征血细胞的生化和物理特性，它们的 膜和粘合剂分子，因为这些特性对 红细胞和白细胞的成熟；有助于在 微循环；以及它们与微血管炎症有关 反应和闭塞现象。努力的重点是生理上的 细胞成熟和激活的过程，在微血管系统中流动 (包括细胞与内皮细胞的黏附和闭塞)，以及运输 氧，并结合临床问题的实验方法 具有工程分析和理论贡献的重要性 科学家和生物物理学家。用于研究的模型障碍包括镰刀 细胞疾病、遗传性球形红细胞增多症、糖尿病、白血病和 输精管闭塞障碍。建议的项目包括：(1) 黏附分子与血细胞相互作用的研究 和内皮细胞表面，在流动条件下，和粘附性 过程；(2)成熟血细胞力学性质的研究 以及它们如何影响血液微循环；(3)对照检查 微血管血流的机制，包括对存在的反应 改变的血细胞；(4)现实的开发和利用 微血管血流的数学模型；(5)模型的推广 为微循环流动的研究提供理论研究 解释观察到的细胞相互作用的流体力学基础。三 核心单位提供行政职能，一个流式细胞仪实验室 服务，以及全面的图像分析系统。

The objective of this study of blood rheology and hemodynamics in normal and pathological models is a collaborative interdisciplinary effort to characterize the biochemical and physical properties of blood cells, their membranes and adhesive molecules, as these properties have significance to maturation of erythrocytes and leukocytes; contribute to flow behavior in the microcirculation; and as they pertain to microvascular inflammatory response and occlusive phenomena. The efforts focus on the physiological processes of cell maturation and activation, flow in the microvasculature (including cell adhesion to endothelium, and occlusion), and transport of oxygen, and combine the experimental approaches to issues of clinical importance with analytical and theoretical contributions of engineering scientists and biophysicists. Model disorders for study include sickle cell disease, hereditary spherocytosis, diabetes, leukemias and vaso-occlusive disorders. The proposed projects include: (1) Investigations of the interactions of adhesion molecules with blood cell and endothelial cell surfaces, under flow conditions, and the adhesion processes; (2) Studies of the mechanical properties of maturing blood cells and how they affect blood microcirculation; (3) Examination of control mechanisms of microvascular blood flow, including responses to the presence of altered blood cells; (4) Development and utilization of realistic mathematical models of microvascular blood flow; and (5) Extension of model and theoretical studies of studies of microcirculatory flow to provide hydrodynamic bases for interpreting observed cellular interactions. Three core units provide administrative functions, a flow cytometry laboratory service, and a comprehensive image analysis system.