BARRIER CONTRACEPTION FOR PREVENTION OF STD

预防性病的屏障避孕

• 批准号: 2371410
• 负责人: MAURIZIO MACALUSO
• 金额: $ 151.86万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1998-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2371410
• 关键词: BARRIER; CONTRACEPTION; PREVENTION; STD

This procurement will produce a multiple arm observational study of women using various barrier contraceptive regimens for the prevention of the following sexually transmitted diseases (STDs): gonorrhoea and chlamydia. This study will determine the maximum possible protection against sexually transmitted diseases provided by consistent and correct use of barrier contraceptives. Secondary endpoints of interest will be the occurrence of other sexually transmitted diseases and pregnancy as detected during the study. The study design will include an educational and motivational component in order to assure an adequate number of participants with continued high levels of barrier use. Because of the personal nature of the decision to use a barrier method, the educational and motivational intervention will be aimed at all study participants, and subjects will choose which method (or no method) they will use during the follow-up period. A typical control group will not exist, the controls being intervention recruits who choose not to use a barrier method during the study. The study will determine: (1) the maximum extent to which various barrier contraceptive methods, used individually or in combination, can protect women from infection with Neisseria gonorrhoea and Chlamydia trachomatis; (2) evidence for the prevention of other STDs and pregnancy by consistent and proper barrier contraceptive use during the course of the study; (3) the correlates of failure (i.e. nonuse, improper use, condom breakage or slippage, other method failure); (4) local toxicity attributable to use of chemical or physical barrier contraceptive methods.

此次采购将产生一项多组观察性研究， 使用各种屏障避孕法预防 下列性传播疾病：淋病和 衣原体 这项研究将确定最大可能的保护 性传播疾病的预防和控制 使用屏障避孕药。 关注的次要终点为 发生其他性传播疾病和怀孕， 在研究过程中检测到。 研究设计将包括一个教育性的 和激励成分，以确保足够数量的 参与者继续使用高水平的屏障。 因为 决定使用障碍法的个人性质，教育 动机干预将针对所有研究参与者， 受试者将选择他们将使用的方法（或不使用方法） 在随访期间。 一个典型的控制组将不存在， 对照组是选择不使用屏障的干预新兵， 方法在研究中。 该研究将确定： (1)各种屏障避孕方法， 单独或联合使用，可以保护妇女免受感染 淋病奈瑟菌和沙眼衣原体感染; (2)预防其他性病和怀孕的证据， 在避孕过程中， 学习; (3)失败的相关因素（即不使用、不当使用、安全套 断裂或滑动，其他方法失效）; (4)使用化学或物理屏障引起的局部毒性 避孕方法。