SUBCUTANEOUS FAT, BLOOD LIPIDS AND SUBSEQUENT OUTCOME

目前的建议是继续进行一项长期的系列研究， 肥胖水平及其分布以及肥胖的危险因素 心血管疾病 身体肥胖的测量包括人体测量， 水下称重和双能X射线吸收测定法。 风险 心血管疾病的因素包括血压，胆固醇， 甘油三酯，高和低密度脂蛋白，载脂蛋白， 空腹血糖胰岛素和某些激素 重要的新系列 将从800多名青少年和成年参与者中收集数据， Fels纵向研究，以扩展系列记录并收集 更多变量。 这项独特研究的新数据和现有数据， 这项始于1929年的研究将被用来更好地了解脂肪 和正常人的脂肪分布。 它还将允许一个 确定哪些因子，与辅因子， 使儿童和/或成年人易患高水平的身体 肥胖，并发展高水平的身体肥胖和风险， 心血管疾病 该项目有三组具体目标： 1)研究儿童期和成年期身体的一系列变化， 组成、脂肪相关变量和心血管疾病的风险因素 疾病，并研究这些变化模式之间的关联， 变量， 2)来检验身体成分脂肪组织 心血管疾病危险因素的分布和生活方式 变量和 3)开发，实施和验证身体研究的新方法 混合物.

The present proposal is for continuation of a long-term serial study of levels of body fatness and its distribution as well as risk factors for cardiovascular disease. Measures of body fatness include anthropometry, underwater weighing, and dual energy X-ray absorptiometry. The risk factors for cardiovascular disease include blood pressure, cholesterol, triglycerides, high and low density lipoproteins, apolipoproteins, fasting glucose, insulin, and certain hormones. Important new serial data will be collected from over 800 juvenile and adult participants in the Fels Longitudinal Study to extend the serial records and collect additional variables. New and existing data from this unique study, which began in 1929, will be used to allow a better understanding of fat and fat-distribution in normal individuals. It will also allow a determination of which factors, in association with co-factors, predispose individuals as children and/or adults to high levels of body fatness, and to develop high levels of body fatness and risk for cardiovascular disease. There are three groups of specific aims for this project: 1) to study serial changes during childhood and adulthood in body composition, fat-related variables, and risk factors for cardiovascular disease and to study associations among patterns of change in these variables, 2) to examine associations among body composition, adipose tissue distribution risk factors for cardiovascular disease, and lifestyle variables, and 3) to develop, implement, and validate new methods for the study of body composition.