BIOCHEMISTRY OF THE CANCER CELL

我们的工作集中在与恶性肿瘤相关的分子事件上。 转化与细胞增殖的控制。正常细胞 通常在恶性细胞继续存在的情况下停止分裂 分裂。我们工作的一个主要目标是描述生物化学 引导非增殖细胞穿过细胞的途径 周而复始。因此，生长因子对细胞分裂的刺激，通过 促进肿瘤的佛波酯，或通过表达转化基因 产品正在研究中。许多关键的蛋白质参与了 早期的步骤位于细胞的质膜或细胞质中。 我们正在尝试确定传输到的信号的性质 导致细胞分裂的核。可逆蛋白质 磷酸化似乎在调节其中一些早期起着重要作用。 生化事件。因此，潜在的相关蛋白激酶， 磷酸蛋白磷酸酶及其底物的纯化和 特色化的。

Our work focuses on the molecular events involved in malignant transformation and the control of cellular proliferation. Normal cells often cease division under conditions in which malignant cells continue to divide. A major goal of our work is the description of the biochemical pathways that lead nonproliferating cells to proceed through the cell cycle. Thus, the stimulation of cell division by growth factors, by tumor-promoting phorbol esters, or by the expression of transforming gene products is under study. Many of the key proteins that participate in the early steps are located in the plasma membrane or cytoplasm of the cell. We are attempting to determine the nature of the signals transmitted to the nucleus that result in cell division. Reversible protein phosphorylation appears to be important in regulating some of these early biochemical events. Therefore, the potentially relevant protein kinases, phosphoprotein phosphatases, and their substrates are purified and characterized.