课题基金 / 基金详情

GENE TRANSFER TO SKELETAL MUSCLE FIBERS AND ENDOTHELIUM

GENE TRANSFER TO SKELETAL MUSCLE FIBERS AND ENDOTHELIUM
基因转移至骨骼肌纤维和内皮
批准号：
2029007
负责人：
Louis Michael Messina
金额：
$24.98万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
项目状态：
已结题
起止时间：
1994-04-09 至 2000-07-31
来源：
https://reporter.nih.gov/project-details/2029007
关键词：
Macaca fascicularis disease /disorder model dystrophin gene expression gene therapy laboratory mouse laboratory rat limb injury muscle metabolism muscular dystrophy nitric oxide synthase nonhuman therapy evaluation regeneration striated muscles tissue /cell culture transfection /expression vector vascular endothelial growth factors vascular endothelium

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DESCRIPTION: (Adapted from the applicant's abstract) This application is for continued funding to develop optimal transduction efficiency in skeletal muscle capillary endothelium and muscle fibers during vascular isolation of the hindlimb, and to determine the efficacy of these approaches to achieve therapeutic concentrations of appropriate recombinant proteins (VEGF, eNOS and dystrophin) in animal models, and finally to determine whether this approach can be accomplished using a catheter-based technique. In preliminary data from this group, high transduction efficiencies have been obtained without evidence of muscle injury or necrosis. These experiments are directed at optimizing the methods rather than at obtaining a therapeutic result.
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