HIV/AIDS HEALTH STATUS MEASURE--CREATION AND VALUATION

威廉·C·霍姆斯博士，美国国家研究服务奖获得者 宾夕法尼亚大学普通内科 医学中心，正在申请临床科学家导师发展计划 为了发展和提高一名学者所需的技能而授予的 独立调查员的职业生涯。候选人的研究兴趣 重点评估艾滋病毒/艾滋病患者的健康状况结果， 特别强调制定健康状况措施。这 应用程序请求支持，以允许Dr.Holmes完成 包括课程作业在内的独立调查员发展计划 进一步加强健康状况测量的知识，并导致 流行病学博士，指导和咨询专家 健康状况测量，以及完成一项研究方案 将在以艾滋病毒/艾滋病为目标的领域取得重要进展 健康状态测量。 艾滋病毒感染仍然是导致本地区死亡和残疾的日益严重的原因 国家和世界。受影响的个人面临着 不是他们这个年龄段的典型的生活问题，也不是他们普遍的 好的，健康状况。因此，现有的一般生活质量 措施(无论是否经过修改以用于艾滋病毒/艾滋病人群) 没有充分评估广泛而复杂的生活质量问题 血清阳性的人。艾滋病毒的生活质量定义的健康状态 血清阳性的个体也仍然没有定义，偏好也是如此 对于这样的健康状况。 这项申请提出了一个五年三阶段的研究计划， 在初步研究的基础上，制作了一个早期版本的 艾滋病毒/艾滋病-有针对性的生活质量测量。建议的第一项研究是 纵向设计，其目的是评估重测 在HIV血清阳性者中，两者的可靠性和反应性 众所周知的通用生活质量测量(例如，SF-36)和 初步的工具。第二项研究在设计上是横断面的， 旨在评估“核心加--”的心理测量特性 模块“工具，它组合了来自通用的 在研究一中评估的测量，与初步的测量， 以艾滋病毒/艾滋病为目标的仪器。委员会提供的共识意见如下： 艾滋病临床试验小组结果委员会将决定 核心加模块仪器的组成。人的心理测量学特性 在初步研究和研究一中确定的仪器将指导 决定。这一工具将使人们能够比较艾滋病毒人口 与其他患病和健康人群(通用核心)合作，同时提供 评价针对艾滋病毒/艾滋病的关切问题(针对艾滋病毒/艾滋病的单元)。这个 第三项研究将使用核心+模块措施来定义艾滋病毒/艾滋病- 具体的健康状况，也是由 结果委员会，其偏好将使用 视觉模拟比较法、标准比较法、联合比较法 分析，和差额测量。

Dr. William C. Holmes, a National Research Service Award Fellow in the Division of General Internal Medicine at the University of Pennsylvania Medical Center, is applying for a Mentored Clinical Scientist Development Award in order to develop and enhance the skills necessary for an academic career as an independent investigator. The candidate's research interest focus on assessing health status outcomes of people with HIV/AIDS, with a particular emphasis on the development of health status measures. This application requests support that will allow Dr. Holmes to complete an independent investigator development program that includes coursework further enhancing knowledge of health status measurement and leading to a Ph.D. in Epidemiology, mentorship and consultation with experts in health status measurement, and completion of a research protocol that will generate important advances in the field of HIV/AIDS-targeted health status measurement. HIV infection remains a growing cause of death and disability in this country and the world. Affected individuals are faced with quality of life concerns that are not typical for their age group nor their generally well health status. As a result, existing generic quality of life measures (whether modified for use in the HIV/AIDS population or not) do not adequately assess the broad and complex quality of life concerns of seropositive individuals. Quality-of-life-defined health states of HIV seropositives individuals remain undefined as well, as do the preference for such health states. This application proposes a five-year, three-phase research plan, building on preliminary studies the produced an early version of an HIV/AIDS-targeted quality of life measure. The first study proposed is longitudinal in design, the aim of which is to evaluate test-retest reliability and responsiveness, in HIV seropositive individuals, of both a well-known, generic quality of life measure (e.g., SF-36) and the preliminary instrument. The second study is cross-sectional in design, and is intended to assess psychometric properties of a "core-plus- module" instrument, one that combines dimensions from the generic measure, evaluated in study one, with those from the preliminary, HIV/AIDS-targeted instrument. Consensus opinion offered by the - Outcomes Committee of the AIDS Clinical Trial Group will determine the make-up of the core-plus-module instrument. Psychmetric properties of the instruments, determined in preliminary studies and study one, will guide decisions. This instrument will allow comparison of the HIV population with other diseased and well populations (generic core), while providing appraisal of HIV/AIDS-targeted concerns (HIV/AIDS-targeted module). The third study will use the core-plus-module measure to define HIV/AIDS- specific health states, again determined by consensus opinion of the Outcomes Committee, for which preferences will be measured using comparative methods of visual analogue scale, standard gamble, conjoint analysis, and difference measurement.