HIV/AIDS HEALTH STATUS MEASURE--CREATION AND VALUATION

艾滋病毒/艾滋病健康状况衡量标准——创建和评估

• 批准号: 2386767
• 负责人: WILLIAM C HOLMES
• 金额: $ 8.14万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2386767
• 关键词: AIDS; HIV infections; behavior test; behavioral /social science research tag; clinical research; data collection methodology /evaluation; functional ability; health surveys; human subject; longitudinal human study; outcomes research; psychometrics; quality of life

Dr. William C. Holmes, a National Research Service Award Fellow in the Division of General Internal Medicine at the University of Pennsylvania Medical Center, is applying for a Mentored Clinical Scientist Development Award in order to develop and enhance the skills necessary for an academic career as an independent investigator. The candidate's research interest focus on assessing health status outcomes of people with HIV/AIDS, with a particular emphasis on the development of health status measures. This application requests support that will allow Dr. Holmes to complete an independent investigator development program that includes coursework further enhancing knowledge of health status measurement and leading to a Ph.D. in Epidemiology, mentorship and consultation with experts in health status measurement, and completion of a research protocol that will generate important advances in the field of HIV/AIDS-targeted health status measurement. HIV infection remains a growing cause of death and disability in this country and the world. Affected individuals are faced with quality of life concerns that are not typical for their age group nor their generally well health status. As a result, existing generic quality of life measures (whether modified for use in the HIV/AIDS population or not) do not adequately assess the broad and complex quality of life concerns of seropositive individuals. Quality-of-life-defined health states of HIV seropositives individuals remain undefined as well, as do the preference for such health states. This application proposes a five-year, three-phase research plan, building on preliminary studies the produced an early version of an HIV/AIDS-targeted quality of life measure. The first study proposed is longitudinal in design, the aim of which is to evaluate test-retest reliability and responsiveness, in HIV seropositive individuals, of both a well-known, generic quality of life measure (e.g., SF-36) and the preliminary instrument. The second study is cross-sectional in design, and is intended to assess psychometric properties of a "core-plus- module" instrument, one that combines dimensions from the generic measure, evaluated in study one, with those from the preliminary, HIV/AIDS-targeted instrument. Consensus opinion offered by the - Outcomes Committee of the AIDS Clinical Trial Group will determine the make-up of the core-plus-module instrument. Psychmetric properties of the instruments, determined in preliminary studies and study one, will guide decisions. This instrument will allow comparison of the HIV population with other diseased and well populations (generic core), while providing appraisal of HIV/AIDS-targeted concerns (HIV/AIDS-targeted module). The third study will use the core-plus-module measure to define HIV/AIDS- specific health states, again determined by consensus opinion of the Outcomes Committee, for which preferences will be measured using comparative methods of visual analogue scale, standard gamble, conjoint analysis, and difference measurement.

William C.博士霍姆斯是美国国家研究服务奖的研究员， 宾夕法尼亚大学普通内科 医学中心，正在申请指导临床科学家发展 奖励，以发展和提高必要的学术技能 作为一名独立调查员。 候选人的研究兴趣 重点评估艾滋病毒/艾滋病感染者的健康状况结果， 特别强调制定健康状况衡量标准。 这 应用程序请求支持，将允许福尔摩斯博士完成一个 独立调查员发展计划，包括课程 进一步提高对健康状况测量的认识， 博士在流行病学，指导和咨询专家， 健康状况测量，并完成一项研究协议， 将在艾滋病毒/艾滋病领域取得重要进展， 健康状况测量。 艾滋病毒感染仍然是这一地区死亡和残疾的一个日益严重的原因。 国家和世界。 受影响的个人面临的质量 生活问题，不是典型的为他们的年龄组，也不是他们的一般 健康状况良好。 因此，现有的一般生活质量 措施（无论是否修改用于艾滋病毒/艾滋病人群） 没有充分评估广泛而复杂的生活质量问题， 血清阳性个体。 生活质量定义的艾滋病毒健康状况 血清阳性个体仍然不确定，以及偏好 这样的健康状态。 该申请提出了一个五年三阶段的研究计划， 在初步研究的基础上， 针对艾滋病毒/艾滋病的生活质量衡量标准。 第一项研究建议， 纵向设计，其目的是评价重测 可靠性和反应性，在艾滋病毒血清阳性的个人， 一种公知的、通用的生活质量测量（例如，SF-36）和 初步文书。 第二项研究是横断面设计， 并旨在评估“核心加- 模块”工具，它结合了通用的维度 在第一项研究中， 针对艾滋病毒/艾滋病的文书。 一致意见由- 艾滋病临床试验组的结果委员会将决定 核心加模块仪器的组成。 的Psychmetric属性 在初步研究和研究一中确定的工具将指导 决策该工具将允许对艾滋病毒感染者进行比较 与其他患病和健康人群（通用核心），同时提供 评估针对艾滋病毒/艾滋病的问题（针对艾滋病毒/艾滋病的模块）。 的 第三项研究将使用核心加模块的措施来界定艾滋病毒/艾滋病， 具体的健康状况，同样由委员会的一致意见决定， 成果委员会，其偏好将使用 视觉模拟量表比较法，标准Gamble，联合 分析和差异测量。