Anti-microbial, elastomeric and microporous coatings for metal implants

用于金属植入物的抗菌、弹性体和微孔涂层

• 批准号: 700268
• 金额: $ 3.08万
• 依托单位: ESP TECHNOLOGY LIMITED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Market
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=700268
• 关键词: Anti; microbial; elastomeric; microporous; coatings

Metal implants are used for bone fracture / joint replacement surgery. Osteolysis (activeresorption of living bone) arises when:• Particles are released from the implant & initiate an immune response• Osteoclasts in the bone matrix are subjected to a reduced mechanical load due to stressshielding (arising from non-uniform loading)Osteolysis causes holes in bones which results in bone weakness, implant loosening andincreased incidence of infection. ESP Technology Ltd plans to develop an orthopaedicimplant coating which can be applied to the bone contact regions of metal implants topromote rapid osteointegration (implant fixation), reduce osteolysis & infections.

金属植入物用于骨折/关节置换手术。骨溶解（活骨的主动吸收）发生在以下情况：•颗粒从植入物中释放并启动免疫反应•骨基质中的破骨细胞由于应力屏蔽（由非均匀负载引起）而受到减少的机械负荷。骨溶解导致骨孔，导致骨无力，植入物松动和感染发生率增加。ESP科技有限公司计划开发一种骨科植入涂层，可应用于金属植入物的骨接触区域，以促进快速骨整合（植入物固定），减少骨溶解和感染。