CASE CONTROL STUDY OF HEMIFACIAL MICROSOMIA AND DRUG USE

描述：(改编自《调查者摘要》)半面部矮小症 (HFM)是第二种最常见的颅面畸形，具有显著的 功能性和美观性后果。虽然实验证据表明 作为一种血管病因学，目前还没有发表的流行病学研究。 HFM的风险因素，其原因在很大程度上仍不清楚。建议数 该项目是一项与1)有关的HFM多中心病例对照研究 母亲暴露于减充血剂，2)母亲暴露于其他血管活性物质 药物(如酒精、咖啡、香烟、阿司匹林和布洛芬)， 3)产妇暴露于其他环境风险因素(如其他 药物、疾病和营养因素)；以及4)最终研究 可能的基因和环境的相互作用。将有250例婴儿感染 HFM和750名无先天性畸形或内科疾病的对照婴儿 需要住院治疗的情况。病例将在12个月内确诊 在15个大都会地区的三级护理机构的年龄 美国和加拿大。对照将通过病例婴儿的主要情况来确定 他是一名内科医生，将包括病例后出生的下三名婴儿。 病例和控制组的母亲将在三个月内接受采访 通过电话确定案件的日期。标准化问卷 详细询问人口统计因素；生殖、医学和 怀孕病史；用药情况；行为和营养。 在面谈之前，每位母亲都会收到一份用药证明 小册子包括非处方药产品的彩色图片，以帮助召回。 这项研究的另一个组成部分是收集口腔细胞样本 从被研究的婴儿及其母亲和父亲那里。标准化 将拍摄照片，并将每个病例婴儿的医疗记录 对HFM分类进行了审查。暴露的流行程度将被比较 病例母亲和对照母亲之间的关系以及相对风险将被估计， 同时控制潜在的混杂因素。

DESCRIPTION: (Adapted from Investigator's Abstract) Hemifacial microsomia (HFM), the second most common craniofacial malformation, has significant functional and cosmetic consequences. While experimental evidence suggests a vascular etiology, there have been no published epidemiologic studies of risk factors for HFM, and its causes remain largely unknown. The proposed project is a multicenter case-control study of HFM in relation to 1) maternal exposure to decongestants, 2) maternal exposure to other vasoactive agents (such as alcohol, coffee, cigarette smoking, aspirin, and ibuprofen), 3) maternal exposure to other environmental risk factors (such as other medications, illness and nutritional factors); and 4) eventual studies of possible gene/environment interactions. There will be 250 case infants with HFM and 750 control infants without congenital malformations or medical conditions requiring hospitalization. Cases will be identified within 12 months of age at tertiary care institutions in 15 metropolitan areas in the U.S. and Canada. Controls will be identified by the case infant's primary physician and will comprise the next three infants born after the case. Mothers of cases and controls will be interviewed within three months after the date of case ascertainment by telephone. The standardized questionnaire inquires in detail about demographic factors; reproductive, medical and pregnancy illness histories; medication use; behaviors; and nutrition. Before the interview, each mother will be sent a medication identification booklet which includes color pictures of OTC products to help with recall. A separate component of the study will be collection of buccal cell samples from the study infant and his/her mother and father. Standardized photographs will be taken and the medical record of each case infant will be reviewed for HFM classification. Exposure prevalences will be compared between mothers of cases and controls and relative risks will be estimated, while controlling for potential confounding factors.