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MECHANISMS OF RETINOID ACTION IN THE UTERUS

MECHANISMS OF RETINOID ACTION IN THE UTERUS
类维生素A在子宫中的作用机制
批准号：
2403636
负责人：
PETER J DAVIES
金额：
$10.0万
依托单位：
UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-01 至 2000-08-31
来源：
https://reporter.nih.gov/project-details/2403636
关键词：
biological signal transduction cell growth regulation estrogens female gene expression hormone regulation /control mechanism laboratory rat retinoid binding proteins retinoids uterus

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中文摘要
翻译
描述(改编自申请人的摘要)：本研究方案 旨在研究雌激素和维甲酸的分子基础 子宫增殖的调控。目标1是确定RAR 维甲酸对雌激素诱导作用的信号通路 子宫增殖，即RAR/RAR、RAR/RXR或RXR/RXR二聚体，以及 RXR/其他蛋白质杂二聚体。目标2是确定 内源性维甲酸对雌激素诱导的子宫的调节作用 扩散。目标3是确定涉及到的分子机制 维甲酸对雌激素调控基因表达的影响 子宫。
英文摘要
DESCRIPTION (Adapted from the applicant's abstract): This research proposal is designed to investigate the molecular basis of estrogens and retinoids in the regulation of uterine proliferation. Aim 1 is to identify the RAR signaling pathways that mediate the effect of retinoids on estrogen-induced uterine proliferation, i.e. RAR/RAR, RAR/RXR, or RXR/RXR dimers, as well as RXR/other protein hetero-dimers. Aim 2 is to determine the role of endogenous retinoids in the regulation of estrogen-induced uterine proliferation. Aim 3 is to identify the molecular mechanisms involved in the effects of retinoids on estrogen-regulated gene expression in the uterus.
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Gulf Coast Consortia (GCC) Research Evaluation and Commercialization Hub
Support for the Human Subjects Protection Program at UTH
Support for the Human Research Protection Program
CONSTRUCTION OF ANIMAL FACILITY
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