TRANSMURAL DEFORMATION

描述(改编自申请人的摘要)：细胞增厚 不到正常左室壁的三分之一 变厚了。沿解理面分离的收缩变形 板层会产生横向剪切应变。显著径向 纵向和径向周向收缩剪切变形 最近使用有限变形方法发现的 研究员S实验室。在最近的研究中，调查者探索了 这些椎板之间的剪切变形产生的假设 壁加厚。他利用了乳沟平面 室间隔和左心室的走行方向不同 自由墙。调查人员发现，剪切变形是 两个部位出现相反征象，与室壁增厚成正比 初始解理平面角度。这些结果有力地支持了他的观点 假设心肌细胞径向板层的运动 产生增厚的墙体。在本方案中，建模和实验 研究将用来探索墙的这种独特的机制 变厚了。调查员将检验这一假设，即它是 独特的非轴对称心室结构和心内膜至心内膜 产生剪切力的心外膜激活序列。进一步研究 将探索血流动力学因素对横向剪切的调节作用 以及观察到的卵裂面解剖变化的影响 室壁重塑和肥厚在此机制上的作用 变厚了。

DESCRIPTION (adapted from the applicant's abstract): Cell thickening accounts for less then one third of normal left ventricular wall thickening. Systolic deformation along the cleavage planes separating the laminae would produce transverse shear strains. Significant radial longitudinal and radial circumferential systolic shearing deformation has recently been found using a finite deformation approach developed in the investigator s laboratory. In recent studies the investigator explored the hypothesis that shearing deformation between these laminae produces wall thickening. He took advantage of the fact that the cleavage planes course in different directions on the septum and the left ventricular free wall. The investigator found that shearing deformation was of the opposite sign at the two sites and wall thickening was proportional to the initial cleavage plane angle. These results strongly support his hypothesis that motion of radially orientated laminae of myocytes produces wall thickening. In this proposal, modeling and experimental studies will be used to explore this unique mechanism of wall thickening. The investigator will test the hypothesis that it is the unique nonaxisymmetric ventricular architecture and endocardial-to- epicardial activation sequence that produce the shears. Further studies will explore the regulation of transverse shears by hemodynamic factors and the effects of changes in cleavage plane anatomy observed in ventricular remodeling and hypertrophy on this mechanism of wall thickening.