GENETIC ANALYSIS OF NUCLEAR HORMONE RECEPTOR FUN

核激素受体在肿瘤的多个方面发挥关键作用， 发展 它们的异常表达也与 多种形式的癌症。在拟议的研究中，将确定基因 对一种核激素的体内功能很重要 受体，视黄酸X受体或RXR。果蝇的基因筛选 将进行鉴定与果蝇相互作用的因素， RXR同系物，美国药典。Usp，与EcR蜕皮激素联合作用 受体对果蝇的发育至关重要。这些屏幕将识别 直接与USP相互作用的伴侣蛋白以及其他蛋白质， USP信号通路的关键组分。希望这一 研究RXR功能的新方法将提供新的和重要的 深入了解核激素受体的作用机制， 果蝇发育的激素调节。

Nuclear hormone receptors play key roles in multiple facets of development. Their abnormal expression is also strongly implicated in cancer of many forms. In the proposed studies, genes will be identified that are important for the in vivo function of one of the nuclear hormone receptors, the retinoid X receptor or RXR. Genetic screens in Drosophila will be performed to identify factors that interact with the Drosophila RXR homolog, usp. Usp, acting in conjunction with the EcR ecdysone receptor is critical for fly development. These screens will identify partner proteins that interact directly with usp as well as other critical components of the usp signaling pathway. It is hoped that this novel approach to studying RXR function will provide new and important insights into the mechanisms of nuclear hormone receptor action as well as the hormonal regulation of Drosophila development.