TAILORING COGNITIVE BEHAVIORAL TREATMENT FOR CANCER PAIN

针对癌症疼痛定制认知行为治疗

• 批准号: 2385311
• 负责人: Jo Ann Dalton
• 金额: $ 36.87万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2385311
• 关键词: behavioral /social science research tag; cancer pain; clinical research; cognitive behavior therapy; human subject; human therapy evaluation; quality of life

DESCRIPTION (Adapted from the Investigator's Abstract): The purpose of the proposed research is to evaluate the immediate and mid-range effectiveness of cognitive-behavioral treatment (CBT) for cancer pain matched to a diagnostic profile, derived from the Biobehavioral Pain Profile (BPP). A three-group experimental, repeated measures design will compare profile-tailored CBT patients with standard CBT and usual pain-treatment control group patients. Three hundred patients in four sites will be randomly assigned to study arm. CBT treatment will include cognitive-behavioral interventions such as education, guided-imagery, time-contingent interactions, attention-diversion, cognitive restructuring, and relaxation. It is hypothesized that at the end of treatment, patients who receive a CBT protocol matched to their BPP will report less pain intensity, fewer pain behaviors, greater responsiveness to treatment, greater durability of response, less interference of pain with activities, less symptom distress, better mood, functioning, sleep and quality of life, and greater achievement of personal goals than patients who receive standard CBT or usual pain treatment, and that the effect of the profile-tailored treatment will be sustained over time. Patients will be treated weekly for five weeks with assessment at baseline, end of the five weeks, 1- and 6-months post treatment using the Brief Pain Inventory, Symptom Distress Scale, Profile of Mood States, Katz ADL, SF-36, pain history and demographic sheets, and identification of goals and their achievement. Multivariate ANOVA will be used to compare the pre-intervention equivalence of the study groups and multivariate GLM analysis of repeated measures to test the primary hypothesis.

描述（改编自研究者摘要）： 拟议的研究是评估即时和中期的有效性， 癌症疼痛的认知行为治疗（CBT）与 诊断谱，源自生物行为疼痛谱（BPP）。 一 三组实验，重复测量设计将比较 采用标准CBT和常规疼痛治疗的个性化CBT患者 对照组患者。 四个研究中心的三百名患者将 随机分配到研究组。CBT治疗将包括 认知行为干预，如教育，引导意象， 时间相关的互动，注意力转移，认知重构， 和放松. 假设在治疗结束时，患者 接受与BPP相匹配的CBT方案的患者将报告更少的疼痛 强度，更少的疼痛行为，对治疗的反应更好， 反应更持久，疼痛对活动的干扰更少， 减少症状困扰，改善情绪，功能，睡眠和生活质量， 和更大的个人目标的实现比患者谁接受标准 CBT或平时的疼痛治疗，并认为效果的配置文件量身定制 治疗将持续一段时间。 患者将每周接受治疗， 5周，基线评估，5周结束时，1-和 6-治疗后3个月，使用简明疼痛量表、症状困扰量表 量表、情绪状态概况、Katz ADL、SF-36、疼痛史和人口统计学 表，并确定目标及其实现情况。 多元 将使用ANOVA比较研究的干预前等效性 组和多变量GLM分析的重复测量，以检验 主要假设