MESOCORTICAL ANATOMY AND PLASTICITY

这本续篇(17-20年)描述了旨在 探讨大脑边缘中皮质的结构组织 猴子和人脑中的脑叶。在最初的几年里，神经再生 对杏仁核的可塑性进行了研究，并在标题中使用了术语“可塑性” 继续提供赠款，尽管它不再描述 这项研究提出。一个中心目标是研究大脑皮层 将关联区与中脑皮质连接起来的关联轴突。 对这种关系的互补性也进行了研究。在……里面 1989年阿尔茨海默病研究被添加为一个新的方向 它针对的正是调节这种关系的神经元。在 格兰特最后一次竞争性审查与阿尔茨海默氏症有关的双重努力 疾病研究与非人灵长类实验神经解剖学 研究被提出，并获得了贾维茨神经科学奖 调查员奖。在这项提案中，概述了三个新目标。 其中两项涉及人类和猴子的联合调查，目标是 分析布罗德曼的第35和34区。前者将 内嗅中皮层与颞叶等皮质。35区是 在人脑中知之甚少，是最早形成的 阿尔茨海默病中的神经原纤维缠绕。猴子行为 研究将其与联想记忆紧密联系在一起。第34区形成了 前部和内侧内嗅皮质，并含有板层改变 在精神分裂症患者的一些大脑中。它在所有类型中都直接损坏 外伤性内侧颞叶部分突出症的手术治疗 小脑幕切迹。细胞表型和 将为这些地区建立边界，重点放在 投射神经元和内源性神经元。另一个目标仅利用 并将评估与三个神经元相关的神经系统 中脑皮质。具体地说，内嗅神经元的终末野 会被注入逆行示踪剂标记的神经元 在细胞内填充荧光黄以揭示他们的 形态学。在相同的准备中，投射到 特征化的内嗅觉神经元将顺着标记到 建立它们对填充的神经元的假定输入模式。共焦 激光扫描显微镜将用于分析这些制剂。 对于所有目标，这些数据将提供基线神经科学信息 对于已知的与发育、神经功能有关的皮质区域 和精神疾病。这是一项具有成本效益的研究，它借鉴了 非人灵长类动物和人类材料的收集 在哈佛医学院工作了27年(1969-1978) 爱荷华大学(1979年至今)。

This continuation (years 17-20) describes experiments designed to investigate the structural organization of the mesocortices of the limbic lobe in the monkey and human brain. In its initial years, reinnervation of the amygdala was investigated and the term "plasticity" in the title has continued with the grant, although it is not longer descriptive of the research proposed. A central goal has been to investigate cortical association axons that link the association areas with the mesocortices. The reciprocal of this relationship has been investigated as well. In 1989 Alzheimer's disease research was added as a new direction since it targets the exact neurons that mediate this relationship. In the grant's last competitive review dual efforts relating to Alzheimer's disease research and nonhuman primate experimental neuroanatomical research were proposed, and the grant received a Javits Neuroscience Investigator Award. In this proposal, three new aims are outlined. Two deal with combined human and monkey investigations and aim to analyze Brodmann's areas 35 and 34. The former interconnects the entorhinal mesocortices with the temporal isocortices. Area 35 is understood poorly in the human brain and the first to develop neurofibrillary tangles in Alzheimer's disease. Monkey behavioral studies link it closely to associative memory. Area 34 forms the anterior and medial entorhinal cortex and contains laminar alterations in some brains of schizophrenics. It is damaged directly in all types of partial and traumatic herniation of medial temporal lobe through the incisura of the tentorium cerebelli. Cellular phenotypes and boundaries will be established for these areas, focusing both on projection and intrinsic neurons. An additional aim utilizes only the monkey and will assess "three neuron" neural systems related to the mesocortices. Specifically, the terminal fields of entorhinal neurons will be injected with a retrograde tracer and the labeled neurons will be filled intracellularly with Lucifer yellow to reveal their morphology. In the same preparation afferent axons projecting to characterized entorhinal neurons will be anterogradely labeled to establish their putative input patterns to the filled neuron. Confocal laser scanning microscopy will be used to analyze these preparations. For all aims, the data will provide baseline neuroscience information for cortical areas known to be involved in developmental, neurological and psychiatric disease. It is cost effective research that draws on a collection of non-human primate and human material gathered over the past 27 years at Harvard Medical School (1969-1978) and The University of Iowa (1979-present).