The development of a hand held, point of care, device by Kanichi Research Services Ltd to measure ammonia in breath as a new approach for the immediate diagnosis,treatment and monitoring of Helicobacter Pylori infection facilitating mass population screen

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There has been a considerable research into chemicals in breath linking their presence, orexcess, with disease or disorders. There are over 30 diseases where research has made thislink. Current diagnosis is often dependent on the analysis of blood, saliva,urine and stools. Itcan beinvasive or unpleasant for the individual, and there can be significant Laboratory delays inobtaining results. A point of care hand held device capturing breath for speedy diagnosis andmanagement of disease has high potential for use by medical professionals and for homemonitoring.Kanichi plans to develop a platform technology measuring chemicals in breath usingelectrochemical sensors housed within a portable breath collection device. Our first target isammonia. This is because our initial market research showed that elevated levels of ammoniahave been associated with nine different medical conditions and as such a device could havemultiple applications. The two most attractive indications were determined to be the point ofcare measurement of the effectiveness of dialysis in end stage renal disease, and in thediagnosis of Helicobacter Pylori infection.These two indications were extensively researched in 2013 through a TSM POM project. Theoutcome was that a need was not established for the dialysis application but that strongsupport was received from Medical consultants and researchers for a better method forHelicobacter Pylori diagnosis and immediate treatment.Kanichi has developed patented electrochemical sensors which measure at the required 100'sppb level. We have also designed a concept for collection of the ammonia in breath forpresentation to the sensor. The purpose of this project is to prove this concept and develop abasic working prototype in collaboration with an industrial partners specialising in gas sensingand medical device development and marketing. We will also refine our knowledge of themarket space and determine our entry strategy