The development of a hand held, point of care, device by Kanichi Research Services Ltd to measure ammonia in breath as a new approach for the immediate diagnosis,treatment and monitoring of Helicobacter Pylori infection facilitating mass population screen

Kanichi 研究服务有限公司开发了一种手持式护理点设备，用于测量呼吸中的氨，作为立即诊断、治疗和监测幽门螺杆菌感染的新方法，促进大规模人群筛查

• 批准号: 710485
• 金额: $ 11.78万
• 依托单位: KANICHI RESEARCH SERVICES LIMITED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710485
• 关键词: development; hand; held; point; care

There has been a considerable research into chemicals in breath linking their presence, orexcess, with disease or disorders. There are over 30 diseases where research has made thislink. Current diagnosis is often dependent on the analysis of blood, saliva,urine and stools. Itcan beinvasive or unpleasant for the individual, and there can be significant Laboratory delays inobtaining results. A point of care hand held device capturing breath for speedy diagnosis andmanagement of disease has high potential for use by medical professionals and for homemonitoring.Kanichi plans to develop a platform technology measuring chemicals in breath usingelectrochemical sensors housed within a portable breath collection device. Our first target isammonia. This is because our initial market research showed that elevated levels of ammoniahave been associated with nine different medical conditions and as such a device could havemultiple applications. The two most attractive indications were determined to be the point ofcare measurement of the effectiveness of dialysis in end stage renal disease, and in thediagnosis of Helicobacter Pylori infection.These two indications were extensively researched in 2013 through a TSM POM project. Theoutcome was that a need was not established for the dialysis application but that strongsupport was received from Medical consultants and researchers for a better method forHelicobacter Pylori diagnosis and immediate treatment.Kanichi has developed patented electrochemical sensors which measure at the required 100'sppb level. We have also designed a concept for collection of the ammonia in breath forpresentation to the sensor. The purpose of this project is to prove this concept and develop abasic working prototype in collaboration with an industrial partners specialising in gas sensingand medical device development and marketing. We will also refine our knowledge of themarket space and determine our entry strategy

对呼吸中的化学物质进行了大量的研究，将它们的存在、过量与疾病或失调联系起来。有超过30种疾病的研究表明了这一点。目前的诊断通常依赖于对血液、唾液、尿液和粪便的分析。它可能是侵入性的或令人不快的个人，并可能有显着的实验室延迟获得结果。一种用于快速诊断和管理疾病的即时手持呼吸采集设备，对于医疗专业人员和家庭监护来说具有很高的潜力。Kanichi计划开发一种平台技术，使用便携式呼吸采集设备中的电化学传感器测量呼吸中的化学物质。我们的第一个目标是氨。这是因为我们最初的市场研究表明，氨水平升高与九种不同的医疗条件有关，因此这种设备可能有多种应用。两个最有吸引力的适应症被确定为终末期肾病透析有效性的床旁测量和幽门螺杆菌感染的诊断。这两个适应症在2013年通过TSM POM项目进行了广泛研究。结果是，没有建立对透析应用的需求，但从医学顾问和研究人员那里得到了更好的幽门螺杆菌诊断和立即治疗方法的强烈支持。Kanichi开发了专利电化学传感器，其测量所需的100'sppb水平。我们还设计了一个概念，用于收集呼吸中的氨，以呈现给传感器。该项目的目的是证明这一概念，并与专门从事气体传感和医疗设备开发和营销的工业合作伙伴合作开发基本工作原型。我们还将完善我们对市场空间的了解，并确定我们的进入战略