AFFECTIVE DISORDERS--AN EXPLORATION OF LONG TERM COURSE

描述（申请人的摘要）：在1978年和1981年之间，NIMH 协作抑郁症研究进行了全面的基线评估， 955例情感障碍先证者。 先证者随访时间为 每半年和每年一次，直至10年，留存率为70.1% 那些还活着的人。 目前正在进一步扩大这一后续行动， 到1996年底，将有一个完整的16年随访。 但是，用于延长后续行动的U01赠款不包括支助 用于数据分析。 爱荷华州中心的调查人员通过以下途径获得了这一结果： R01机制，并利用三年的支持， 期刊文章描述了10年来情感性疾病的过程， 期 我们现在寻求一个有竞争力的更新，以分析数据，从整个18 年 早期的CDS分析强调了指数发作的过程， 至后续临床事件的时间和长期预后 基线测量的质量。 从那以后，我们把重点转移到了 前瞻性观察事件的时间和现象学， 重复观察的趋势明显。 未来的性质 现有的评估提供了前所未有的机会， 长期病程的主要情感障碍无偏见 试图回忆起遥远的事件。 此外，新提供的 统计学方法将允许评估治疗效果， 发病率和自杀风险。

DESCRIPTION (Applicant's Abstract): Between 1978 and 1981, the NIMH Collaborative Depression Study conducted thorough baseline evaluations of 955 probands with major affective disorder. Probands were followed at semiannual and annual intervals to 10 years with a retention rate of 70.1% of those still living. A further extension of this follow-up is currently underway and a full 16-year follow-up will be available by the end of 1996. The U01 grant for the extended follow-up, however, did not include support for data analysis. Investigators at the Iowa Center obtained this through the R01 mechanism and used the three years of support to produce 18 refereed journal articles describing the course of affective illness over a 10-year period. We now seek a competitive renewal to analyze data from the full 18 years. Earlier CDS analyses have emphasized the course of index episodes, the time to subsequent clinical events, and the long-range prognostic qualities of baseline measures. We have since shifted emphasis to the timing and phenomenology of prospectively observed episodes and to overall trends apparent across repeated observations. The prospective nature of the available assessments provides unprecedented opportunities to describe the long-term course of the major affective disorders without the biases attending attempts to recall remote events. Moreover, newly available statistical methods will allow the assessment of treatment effects on morbidity and risk for suicide.