Evolving rates: foundations for the next generation of molecular clocks

进化速率：下一代分子钟的基础

• 批准号: DP190101916
• 负责人: Prof Lindell Bromham
• 金额: $ 32.48万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-03 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101916
• 关键词: Evolving; rates; foundations; next; generation

This project aims to investigate the causes and consequences of variation in rate of DNA sequence evolution across three kingdoms of life. Dates estimated from DNA sequences have a wide range of applications, including evolutionary biology, conservation prioritisation and epidemiology. These methods rely on accurate rate estimates, but current models lack information about the biological drivers of rates of genomic change. This project will test reliability of current methods, identify potentially misleading estimates of disease origin or conservation priorities, and develop new approaches with empirically-informed models of rate change.

该项目旨在调查在三个生命王国的DNA序列进化速率变化的原因和后果。从DNA序列估计的日期有广泛的应用，包括进化生物学，保护优先级和流行病学。这些方法依赖于准确的速率估计，但是目前的模型缺乏关于基因组变化率的生物学驱动因素的信息。该项目将测试当前方法的可靠性，确定对疾病起源或保护优先事项的潜在误导性估计，并开发具有经验信息的速率变化模型的新方法。