Innovative, upscalable and ecological process to produce wildtype silk protein solutions

生产野生型丝蛋白解决方案的创新、可升级和生态工艺

• 批准号: 710801
• 金额: $ 9.93万
• 依托单位: OXFORD BIOMATERIALS LTD
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710801
• 关键词: Innovative; upscalable; ecological; process; produce

This 12 months project aims at developing a new economically viable process to produce nonmulberrysilk solutions and to offer scaffolds with increased tissue regenerative potential. Silksolutions extracted from the domesticated Bombyx mori can be assembled into a wide rangeof materials, from hydrogels, films to sponges and composites, all particularly suited tobiomedical applications due to their protein composition. Several varieties of wildtype (or nonmulberry)silkworms have a range of mechanical properties closer to native tissues as well ascellular adhesion motives naturally occuring in their protein sequence, both significantlyenhancing the potential to repair or replace damaged tissue. However the exploitation of theirprotein solutions has been limited so far, as extracting the proteins from their highlycrosslinked fibres requires extensive and hazardous chemicals treatments, preventing futuremanufacture. Under this proof of concept project, OBM will develop a new, ecologicalprocess to produce non-mulberry silk solutions, with potential for upscale andcommercialisation.

这个为期12个月的项目旨在开发一种经济上可行的新工艺来生产非桑蚕丝溶液，并提供具有更高组织再生潜力的支架。从驯化的家蚕中提取的丝素溶液可以组装成从水凝胶、薄膜到海绵和复合材料的各种材料，由于其蛋白质组成，所有这些材料都特别适合生物医学应用。几个品种的野生型(或非桑蚕型)家蚕具有一系列与天然组织更接近的机械特性，以及自然出现在其蛋白质序列中的细胞黏附动机，这两者都显著增强了修复或替换受损组织的可能性。然而，到目前为止，他们的蛋白质解决方案的开发一直受到限制，因为从他们的高交联度纤维中提取蛋白质需要广泛和危险的化学处理，从而阻止了未来的制造。根据这一概念验证项目，OBM将开发一种新的生态工艺来生产非桑蚕丝解决方案，具有升级和商业化的潜力。