AIRWAY RESPONSE TO ENVIRONMENTAL TOXINS

描述：(改编自《调查者摘要》)这个项目是 旨在了解人类通过什么生物化学过程 白细胞输出生物强效的脂质介质--白三烯 (Lt)C4。LTC4是一种强有力的支气管收缩药，已有研究表明 成为导致呼吸道收缩的主要因素。LTC4传输器 调节LTC4的释放，从而潜在地调节 这种介质的局部浓缩。计划研究生化 和生物物理性质与结构功能的关系 这种蛋白质的。为了实现这些目标，调查人员建议 分离和克隆LTC4转运蛋白。一些具体的 提出了实现这一目标的目标，并进一步研究了 LTC4在肺功能减退发病机制中的作用

DESCRIPTION: (Adapted from the Investigator's Abstract) This project is aimed at understanding the biochemical processes by which human leukocytes export the biologically potent lipid mediator, leukotriene (LT) C4. LTC4 is a potent bronchoconstrictor, and has been suggested to be a major contributor to airway constriction. The LTC4 transporter regulates the release of LTC4 and hence potentially regulates the local concentration of this mediator.Plans are to study the biochemical and biophysical properties and the structure function relationship of this protein. To achieve these goals, the investigator proposes to isolate and clone the LTC4 transport protein. A number of specific aims are proposed to achieve this goal and to further investigate the role of LTC4 in the pathogenesis of attenuated pulmonary function.