TRANSITIONS INTO ADULTHOOD--THE BALTIMORE STUDY

描述：（申请人摘要） 这是一项2000多人的纵向研究的拟议扩展 1985-86年首次招募一年级学生作为流行病学样本， 每年通过中学评估。 对于这项研究的扩展， 这些年轻人将在他们的年龄中位数为十七，十八， 和19年。 这个五年计划的主要目标有三个。 首先，我们将测试关于吸毒的早期发病可能是多少的假设。 与后期药物问题风险增加有关 青春期 其次，我们将检验关于童年的其他假设 可能影响风险水平的条件和过程，保护， 和弹性因素，包括行为问题， 不正常的同龄人，以及首次吸毒后可能发生的变化 (e.g.,在家长的监督下）。 可能的效果修饰符集 要研究的媒介包括假设的弹性因素，如 宗教信仰和社会纽带 第三，我们将测试替代假设 关于吸烟和其他药物使用如何影响 精神障碍，并随着时间的推移解释精神并发症。 这项工作将主要关注抑郁症，自我伤害和自杀 尝试. 所有这三个目标都将在一个协调的 时尚，借鉴标准化数据收集的新浪潮， 1997-2000年的纵向流行病学样本。 的长期目标 这个项目是为了确定与 增加青少年吸毒的风险和以后吸毒的风险 依赖综合症 这些特点应进一步保证 在未来的研究中，将评估作为预防干预的目标。

DESCRIPTION: (Applicant's Abstract) This is a proposed extension of a longitudinal study of more than 2000 first-graders first recruited as an epidemiologic sample in 1985-86, and assessed annually through middle school. For this extension of the study, these youths will be interviewed when they are at a median age of 17, 18, and 19 years. The main objectives of this 5 year project are threefold. First, we will test hypotheses about how early onset of drug use might be associated with an increase in risk for drug problems during late adolescence. Second, we will test alternative hypotheses about childhood conditions and processes that might influence levels of risk, protective, and resiliency factors, including conduct problems, affiliations with deviant peers, and possible changes that occur after initial drug-taking (e.g., in parent monitoring levels). The set of possible effect-modifiers and mediators to be studied include hypothesized resiliency factors such as religiosity and social bonds. Third, we will test alternative hypotheses about how tobacco smoking and other drug use might influence the onset of psychiatric disturbances and account for psychiatric comorbidity over time. This work will have a primary focus on depression, self-harm, and suicide attempts. All three of these objectives will be addressed in a coordinated fashion, drawing upon the new waves of standardized data gathering of this longitudinal epidemiologic sample between 1997-2000. The long-term goal of this project is to identify malleable characteristics associated with increased risk for drug involvement in adolescence and later risk of drug dependence syndromes. These characteristics should warrant further evaluation as the targets of preventive interventions in future studies.