BUPRENORPHINE MAINTENANCE--DOSE SCHEDULE AND TX SETTING

因为迫切需要开发美沙酮的替代品来治疗 阿片类药物依赖的维持治疗和扩大 以具有成本效益的方式提供和获得服务， 我们正在提议一项为期24周的随机试验，以评估临床 丁丙诺啡替代维持给药策略的疗效 (每天一次，而每周三次)。这项研究是在传统的 维持计划，比较丁丙诺啡每日维持剂量 (1)和每周三次维持量(2组)。评估 无论是阿片类药物依赖患者，没有重大精神病理或 对酒精、镇静剂或可卡因的依赖可以从减少 频繁给药，受试者(N=90)将被要求满足严格的 资格和排除标准，并将按性别和 随机分配治疗前的就业状况。心理咨询 将对情况进行人工指导和仔细监督，以确保 遵守研究方案和治疗的完整性 接近了。主要结果包括在临床试验中保留， 减少非法阿片类药物和其他药物的使用，减少艾滋病毒 危险行为。

Because of the critical needs to develop alternatives to methadone for the maintenance treatment of opioid dependence and to expand the availability and accessibility of services in a cost-effective manner, we are proposing a 24-week randomized trial that will assess the clinical efficacy of alternative buprenorphine maintenance dosing strategies (daily versus thrice-weekly). The study conducted in a traditional maintenance program, compares daily buprenorphine maintenance dosing (Group 1) and thrice-weekly maintenance dosing (Group 2). To assess whether opioid dependent patients without major psychopathology or dependence on alcohol, sedatives or cocaine can benefit from less frequent dosing, subjects (N=90) will be required to meet stringent eligibility and exclusion criteria and will be stratified by gender and employment status prior to random assignment to treatment. Counseling conditions will be manual-guided and carefully supervised to insure adherence to the study protocol and the integrity of the treatment approaches. Major outcomes include retention in the clinical trial, reductions in illicit opioid and other drug use, and reductions in HIV risk behavior.