课题基金 / 基金详情

PROTEIN LOCALIZATION OF THE YEAST VACUOLE

PROTEIN LOCALIZATION OF THE YEAST VACUOLE
酵母液泡的蛋白质定位
批准号：
2023872
负责人：
BRUCE F HORAZDOVSKY
金额：
$19.09万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-06-01 至 2002-05-31
来源：
https://reporter.nih.gov/project-details/2023872
关键词：
Golgi apparatus guanosinetriphosphatases membrane permeability protein transport vesicle /vacuole yeasts

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项目成果

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英文摘要
DESCRIPTION: The long term goal of this research is to determine the molecular events which underlie the transport of lysosomal proteins to the yeast lysosome-equivalent, the vacuole. This application focuses on a Ras-like GTPase, Vps21p, and a Sec1 homolog, Vps45p, shown to be important in vacuolar protein sorting. Dr. Horazdovsky will define precisely the step at which these proteins act, and begin to look for interacting proteins and their mechanisms of modulation of Vps21p. Other aims include analysis of transport vesicles carrying Golgi derived proteins to the vacuole, and characterization of the proteinase A sorting proteins.
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