PHARMACOKINETICS OF ORAL GANCICLOVIR IN PEDIATRIC PATIENTS

更昔洛韦是一种合成的鸟嘌呤衍生物， 病毒复制，包括巨细胞病毒（CMV）。 述药物是 对CMV治疗和慢性抑制治疗均有效 各种患者的感染。 食药监总局 最近批准了一种口服形式的更昔洛韦， 免疫功能低下CMV视网膜炎患者胃肠外药物治疗 慢性抑制疗法有几个儿科患者群体 可能受益于口服更昔洛韦。 我们研究的目的是 通过测定吸收曲线获得药代动力学数据， 儿童血清中的谷氨酰胺浓度。

Ganciclovir is a synthetic guanine derivative which interferes with the replication of viruses, including cytomegalovirus (CMV). The drug is effective for both treatment and chronic suppressive therapy of CMV infections in a variety of patients. The Food and Drug Administration has recentlyapproved an oral form of ganciclovir as an alternative to parenteral drug in immunocompromised patient with CMV retinitis for chronic suppressive therapy. There are several pediatric patient groups who may benefit from use of oral ganciclovir. The purpose of our study is to obtain pharmacokinetic data by determining the absorption profile and achievalbe serum concentrations in children.