患有脂质代谢紊乱的正常志愿者的放血/血浆置换术-猫眼课题宝

患有脂质代谢紊乱的正常志愿者的放血/血浆置换术

批准号：

2480113

负责人：

金额：

$3.19万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2480113

关键词：

X ray crystallography apolipoprotein E atherosclerosis blood chemistry blood lipoprotein metabolism cardiovascular disorder epidemiology clinical research disease /disorder proneness /risk family genetics human subject inborn lipid /lipoprotein disorder lipid structure phlebotomy plasmapheresis protein structure receptor

中文摘要

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英文摘要

This protocol is used to obtain plasma lipoproteins and apolipoproteins to support a number of research projects in the Gladstone Institute of Cardiovascular Disease. The projects include investigations related to plasma lipoprotein metabolism, atherosclerosis, and neural cell function. The current project is designed to test the hypothesis that primary structure differences (amino acid sequence differences) between the three major isoforms of apolipoprotein-E account for different tertiary structures that affect isoform function in lipoprotein metabolism.

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海外基金

PHLEBOTOMY/PLASMAPHERESIS IN NORMAL VOLUNTEERS W/DISORDERS OF LIPID METABOLISM

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