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DEXRAZOXANE, DOXORUBICIN & ESCALATING DOSES OF PACLITAXEL IN ADVANCED BREAST CA

DEXRAZOXANE, DOXORUBICIN & ESCALATING DOSES OF PACLITAXEL IN ADVANCED BREAST CA
右雷佐生、阿霉素
批准号：
6246868
负责人：
JAMES SPEYER
金额：
$2.39万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-12 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246868
关键词：
antineoplastics breast neoplasms clinical research clinical trial phase I combination chemotherapy doxorubicin drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy paclitaxel pharmacokinetics

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中文摘要
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英文摘要
This Phase I trial will determine the maximum tolerable dose and response rate of paclitaxel that can be combined with doxorubicin and dexrazoxane with and without G-CSF. The effect of dexrazoxane on the pharmokinetics of paclitaxel used in combination with doxorubicin will be assessed. The maximum cumulative dose of doxorubicin that can be given when used in combination with dexrazoxane and paclitaxel will also be assessed.
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Protocol Review and Monitoring
WEEKLY ONE HOUR PACLITAXEL IN REFRACTORY METASTATIC BREAST CANCER
WEEKLY ONE HOUR PACLITAXEL IN REFRACTORY METASTATIC BREAST CANCER
DEXRAZOXANE, DOXORUBICIN & ESCALATING DOSES OF PACLITAXEL IN ADVANCED BREAST CA
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