课题基金 / 基金详情

AG 1343 DOSE FINDING STUDY IN HIV+ PATIENTS

AG 1343 DOSE FINDING STUDY IN HIV+ PATIENTS
AG 1343 HIV 患者的剂量探索研究
批准号：
6246945
负责人：
Martin H Markowitz
金额：
$5.86万
依托单位：
ROCKEFELLER UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-27 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6246945
关键词：
HIV infections antibody titering antiviral agents clinical research dosage drug administration rate /duration drug screening /evaluation human subject human therapy evaluation pharmacokinetics

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英文摘要
The goals of this study are: 1. To evaluate the safety of different doses and/or dose regimens of AG1343 administered with food and 8-12 ounces of water for 4 weeks of monotherapy in HIV positive patients. 2. To assess clinical activity of different doses and/or dose regimens of AG1343 using virologic and immunologic markers of HIV disease progressions, i.e., quantitative plasma HIV RNA titer, absolute CD4/CD8 count and percentage, and p24 antigen level to establish optimum dosing regimen for larger phase II controlled trials. 3. To determine the pharmacokinetics of AG1343 at different doses/dose regimens in HIV positive patients.
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