NONSTEROIDAL AFFINITY LIGANDS FOR THE ANDROGEN RECEPTOR

雄激素受体的非类固醇亲和配体

• 批准号: 2008928
• 负责人: JAMES T DALTON
• 金额: $ 9.19万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2008928
• 关键词: affinity labeling; androgen inhibitor; androgen receptor; animal genetic material tag; ligands; molecular cloning; protein structure function; radiotracer; receptor binding; recombinant proteins; tissue /cell culture

DESCRIPTION (Adapted from the investigator's abstract): This application proposes to 1) design and synthesize affinity labels for the AR; 2) characterize the binding and pharmacological activities of the synthesized compounds; and 3) synthesize radiolabelled versions of promising compounds and employ them as affinity labels. The studies outlined in the final two specific aims are designed to demonstrate the irreversibility of binding and to identify the amino acids to which these compounds have been linked.

描述（改编自研究者摘要）：本申请 提出1）设计和合成AR的亲和标记; 2） 表征合成的化合物的结合和药理活性， 化合物;以及3）合成有前景的化合物的放射性标记形式 并将其用作亲和标记。 在最后两篇文章中概述的研究 具体目标旨在证明约束力的不可逆转性， 来鉴定这些化合物所连接的氨基酸。