BEST DECISION

这项提案要求提供资金，以开发一种创新的互动CD- 只读存储器，“最佳决策”，供个人在决定是否或 不接受乳房遗传易感性的基因测试 癌症。通过初级保健，乳房X光检查，肿瘤学， 遗传学咨询和其他医疗保健环境，“最佳决定” 将适用于办公室和家庭使用，位置是 最适合消费者，并提供一个私人房间， 具有CD-ROM功能的计算机。作为辅助决策的工具， “最佳决策”将呈现标准化的信息和资源 教育妇女1)其个人风险的材料 罹患乳腺癌，无论是由于遗传易感性还是 其他一些因素；2)BRCA1检测的适用性、其风险和 利益；以及3)决策选项和战略，以及 决策选择的相关风险和收益。 建议的商业应用：该光碟将推向 临床遗传学研究站点，乳房X光检查中心，医疗保健组织， 医院，社区卫生中心。它还可以进行定制，以 包括已建立的遗传咨询方案 组织，从而增加其对HMO的适销性，HMO可以 将其作为增值服务提供。

This proposal requests funds to develop an innovative interactive CD- ROM, "Best Decision", for individuals to use when deciding whether or not to undergo genetic testing for inherited susceptibility to breast cancer. Available through primary care, mammography, oncology, genetics counseling, and other health care settings, "Best Decision" will be appropriate for in-office and in-home use, which location is most suitable to the consumer and provides a private room with a computer with CD-ROM capability. As a tool to aid in decision making, "Best Decision" will present standardized information and resource material to educate women regarding 1) their personal risk of developing breast cancer whether due to inherited pre-disposition or some other factor; 2) the suitability of BRCA1 testing, its risks and benefits; and 3) decision-making options and strategies, and the associated risks and benefits of decision choices. PROPOSED COMMERCIAL APPLICATION: The CD-ROM will be marketed to clinical genetics research sites, mammography centers, HMOs, hospitals, community health centers. It also can be customized to include the established genetics counseling protocols of an organization, thereby increasing its marketability to HMOs which can provide it as a value-added service.