SUICIDE ANALOGS FOR HBV THERAPY

乙型肝炎治疗的自杀类似物

• 批准号: 2540178
• 负责人: KYOICHI A WATANABE
• 金额: $ 10万
• 依托单位: CODON PHARMACEUTICALS, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2540178
• 关键词: antiviral agents; drug adverse effect; drug design /synthesis /production; hepatitis B virus group; tissue /cell culture

DESCRIPTION: (adapted from applicant's abstract) Phase I research includes synthesis of potential HBV compunds, screening for activity and short and long term cytotoxicity studies in a cell culture model. Phase II will involve further synthesis of derivatives based on phase I results. Large amounts of promising compounds will be made which will be tested for efficacy and long term toxicity in vitro and in vivo.

描述：（改编自申请人摘要）第一阶段研究 包括合成潜在的HBV化合物，筛选活性， 在细胞培养模型中的短期和长期细胞毒性研究。相 II将涉及在I相的基础上进一步合成衍生物 结果大量有前途的化合物将被制造出来， 在体外和体内测试功效和长期毒性。