COMPUTERIZED 3-D VISUALIZATION OF EMBRYONIC DEVELOPMENT

长期目标是开发软件产品， 利用计算机三维可视化技术研究 哺乳动物胚胎学 现代卫生专业人员需要熟悉 胚胎学，了解正常解剖和出生缺陷的起源。 然而，这个问题是特别难以掌握，因为发展 结构会随着时间发生巨大变化。 计算机的最新进展 用于重建和操作3D图像的硬件和软件 使其能够以低成本展示解剖学发展 软件产品。 拟议项目将测试这一点的可行性 使用10mm猪胚胎作为模型的概念。 重建的三维图像 将使用常规和共聚焦显微镜来制备胚胎。 将使用存档的连续切片或整个固定胚胎进行成像。 在对齐各个图像并校正伪影后， 将重建数据集。 那么，基于代理的软件设计将 用于将这些数据集与相关内容数据库集成。 关键 计划中的原型应用程序的特点将包括易于 定制，以满足特定的课程需求和网络中的功能 环境 该原型将被测试用于医疗，牙科， 兽医课程。 软件专家的互动， 该项目的专家和教育工作者还将提供科学和 技术创新，并确保设计的产品将是 高质量和吸引广泛的卫生专业人员。

DESCRIPTION: The long term objective is to develop software products that utilize computerized 3-D visualization technology for the study of mammalian embryology. Modern health professionals need a familiarity with embryology to understand normal anatomy and the origin of birth defects. Yet, this subject is particularly difficult to grasp since developing structures change dramatically over time. Recent advances in computer hardware and software for reconstructing and manipulating 3-D images now make it feasible to demonstrate anatomical development with low cost software products. The proposed project will test the feasibility of this concept using the 10mm pig embryo as a model. Reconstructed 3-D images of embryos will be made using both conventional and confocal microscopy. Archived serial sections or whole fixed embryos will be used for imaging. After aligning individual images and correcting for artifacts, 3-D image datasets will be reconstructed. Component-based-software design will then be used to integrate these datasets with related content databases. Key features of the planned prototype application will include ease of tailoring to meet specific course needs and functionality in a networked environment. The prototype will be tested for use in the medical, dental and veterinary curricula. The interaction of software experts, imaging specialists, and educators on this project will also offer scientific and technological innovation and ensure that the designed products will be of high quality and appeal to a wide range of health professionals.