COMPUTERIZED 3-D VISUALIZATION OF EMBRYONIC DEVELOPMENT

胚胎发育的计算机化 3D 可视化

• 批准号: 2026295
• 负责人: DAVID A DAMASSA
• 金额: $ 9.98万
• 依托单位: ENVISION DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2026295
• 关键词: computer program /software; computer system design /evaluation; confocal scanning microscopy; digital imaging; image processing; mammalian embryology; swine

DESCRIPTION: The long term objective is to develop software products that utilize computerized 3-D visualization technology for the study of mammalian embryology. Modern health professionals need a familiarity with embryology to understand normal anatomy and the origin of birth defects. Yet, this subject is particularly difficult to grasp since developing structures change dramatically over time. Recent advances in computer hardware and software for reconstructing and manipulating 3-D images now make it feasible to demonstrate anatomical development with low cost software products. The proposed project will test the feasibility of this concept using the 10mm pig embryo as a model. Reconstructed 3-D images of embryos will be made using both conventional and confocal microscopy. Archived serial sections or whole fixed embryos will be used for imaging. After aligning individual images and correcting for artifacts, 3-D image datasets will be reconstructed. Component-based-software design will then be used to integrate these datasets with related content databases. Key features of the planned prototype application will include ease of tailoring to meet specific course needs and functionality in a networked environment. The prototype will be tested for use in the medical, dental and veterinary curricula. The interaction of software experts, imaging specialists, and educators on this project will also offer scientific and technological innovation and ensure that the designed products will be of high quality and appeal to a wide range of health professionals.

描述：长期目标是开发以下软件产品 利用计算机化的三维可视化技术研究 哺乳动物胚胎学。现代卫生专业人员需要熟悉 胚胎学，以了解正常解剖和出生缺陷的来源。 然而，自开发以来，这一主题尤其难以掌握 随着时间的推移，结构发生了巨大的变化。计算机的最新进展 现在用于重建和处理3-D图像的硬件和软件 使以低成本演示解剖发育成为可能 软件产品。拟议的项目将检验这一点的可行性 概念以10 mm的猪胚胎为模型。重建的三维图像 胚胎将同时使用传统显微镜和共聚焦显微镜进行制作。 存档的连续切片或完整的固定胚胎将用于成像。 在对齐单个图像并校正伪影之后，3-D图像 数据集将被重建。然后，基于组件的软件设计 用于将这些数据集与相关内容数据库集成。钥匙 计划中的原型应用程序的功能将包括 量身定制以满足网络环境中的特定课程需求和功能 环境。该样机将进行测试，用于医疗、牙科 和兽医课程。软件专家、图像专家之间的互动 该项目的专家和教育工作者也将提供科学和 技术创新，确保设计的产品符合 高素质和广泛的健康专业人士的吸引力。