Genes underlying enteric neuron subtype differentiation

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This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic developmental neuroscience, by innovative use of Next Generation RNA-sequencing technology to investigate enteric neuron subtype differentiation. The project outcomes include the generation of neuron subtype specific progenitors from naïve stem cells, which will in the longer term have significant health benefits, as gastrointestinal dysfunction is a large health and economic burden in Australia.