GABA RECEPTORS IN ETHANOL PLACE PREFERENCE AND AVERSION

乙醇中 GABA 受体的偏好和厌恶

• 批准号: 2410684
• 负责人: JULIA ANN CHESTER
• 金额: $ 1.99万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2410684
• 关键词: GABA receptor; association learning; avoidance behavior; behavioral /social science research tag; bicuculline; conditioning; ethanol; gamma aminobutyrate; inbreeding; laboratory mouse; motivation; neuropharmacology; preference; reinforcer

The broad, long-term goal of the proposed project is to investigate a role for the GABA neurotransmitter system in modulating the rewarding and aversive properties of ethanol. The proposed studies will utilize the place conditioning paradigm to examine the acquisition of conditioned place preference (CPP) and conditioned place aversion (CPA) in DBA/2J mice. The place conditioning procedure provides a useful model to study the learned association between environmental stimuli and a drug's rewarding and aversive effects, and allows for the investigation of specific neural pathways involved in the acquisition of place conditioning. Although the GABA system has been implicated in mediating many of ethanol's behavioral effects, it has not yet been investigated as a possible modulator of ethanol-induced CPP or CPA. The specific aims of this project are to test various doses of pharmacological antagonists selective for GABAA and GABAB receptor subtypes in the acquisition of ethanol-induced CPP and CPA. These studies will help elucidate the role of GABA in modulating the acquisition of conditioned responses to ethanol's neuropharmacological effects. Overall, the information gained from this project will contribute to an understanding of the neurochemical substrates underlying the motivational effects of ethanol. Studies such as these are important in order to develop appropriate clinical treatments for ethanol-seeking and addictive behavior in humans.

该项目的广泛的长期目标是调查一个角色， GABA神经递质系统在调节奖赏和 乙醇的令人厌恶的特性。 拟议的研究将利用 位置条件反射范式考察条件反射的习得 DBA/2 J中的位置偏爱（CPP）和条件性位置厌恶（CPA 小鼠 位置条件作用程序提供了一个有用的研究模式 环境刺激和药物之间的习得性联系 奖励和厌恶的影响，并允许调查 参与获得位置的特定神经通路 条件反射 虽然GABA系统参与了 尽管乙醇的许多行为影响，但尚未被研究， 乙醇诱导的CPP或CPA的可能调节剂。 的具体目标 本项目旨在测试不同剂量的药理学拮抗剂 选择性GABAA和GABAB受体亚型的收购， 乙醇诱导的CPP和CPA。 这些研究将有助于阐明 GABA在调节条件反应的获得， 乙醇的神经药理作用 总体而言，获得的信息 将有助于理解 神经化学底物的激励作用的乙醇。 这些研究对于制定适当的 人类寻求乙醇和成瘾行为的临床治疗。