MASTER AGREEMENT ORDER FOR CHEMICAL SYNTHESIS

化学合成主协议订单

• 批准号: 3608077
• 负责人: DRURY S CAINE
• 金额: $ 1.86万
• 依托单位: UNIVERSITY OF ALABAMA IN TUSCALOOSA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3608077
• 关键词: analytical chemistry; antiAIDS agent; antineoplastics; chemical synthesis; drug design /synthesis /production; drug metabolism; drug screening /evaluation; heterocyclic compounds; infrared spectrometry; neoplasm /cancer pharmacology; nuclear magnetic resonance spectroscopy; nucleosides; peptides; ultraviolet spectrometry

The contractor shall furnish as required by the Government, on a master agreement order basis, the specific compounds assigned. Assignment of materials for synthesis, as well as the specification of standards of purity and quantity will be provided by the project officer. Specifically, the contractor shall perform the following tasks: 1) Resynthesize specified compounds in half (0.5) to two (2) gram quantities and/or synthesize unique compounds in half (0.5) to two (2) gram quantities. Submit all compounds synthesized to NCI. 2) Establish the identity of each compound synthesized through IR, UV, NMR, and elemental analysis. 3) Assay completely all materials as to their purity and homogeneity. Determine physical and chemical properties such as solubility and stability as required. 4) Submit data sheets for all compounds synthesized, giving pertinent chemical and physical properties in a format acceptable to the project officer. 5) All target compounds must be delivered within the proposed time period after issuance of the master agreement order. In exceptional cases, it may be extended by the mutual agreement of the Contracting Officer and the Contractor. 6) The chemicals and drugs to be prepared or handled under this Master Agreement are to be regarded as proprietary in nature. Under no circumstances are chemicals or drugs or any information associated with these chemicals or drugs to be released or divulged without prior written approval of the Project Officer.

承包商应按照政府的要求， 协议订单的基础上，指定的具体化合物。 转让 用于合成的材料，以及标准的规格 纯度和数量将由项目干事提供。 具体地说， 承包商应执行以下任务：1）重新合成 半（0.5）至两（2）克量的特定化合物和/或 合成一半（0.5）到两（2）克量的独特化合物。 将合成的所有化合物提交给NCI。 2)确立…的身份 通过IR、UV、NMR和元素分析合成的每种化合物。 第三章 完全测定所有材料的纯度和均匀性。 测定溶解度和稳定性等物理和化学性质 按要求 4)提交所有合成化合物的数据表， 相关的化学和物理性质，格式可接受的 项目干事。 5)所有目标化合物必须在 主协议指令发出后的拟议时间段。 在 在特殊情况下，经双方同意， 承包商和承包商。 6)化学药品和毒品 根据本主协议编制或处理的文件应被视为 在性质上是专有的。 在任何情况下，化学品或毒品或 与这些化学品或药物相关的任何信息， 未经项目官员事先书面批准而泄露。