Cysteamine dioxygenases: novel oxygen sensors implicated in hypoxia?

该项目旨在研究和操纵一种新的氧传感系统，半胱胺双加氧酶，以帮助了解哺乳动物细胞如何对低氧浓度（一种称为缺氧的条件）作出反应。世界上一些最具破坏性的疾病会损害氧气输送，改变生物化学景观。通过了解细胞如何对氧气波动做出反应，该项目有望开发出治疗这些有害条件的有效方法。半胱胺双加氧酶的特性可以建立一种新的机制，通过这种机制，细胞可以监测氧气的变化，有助于了解缺氧和疾病。该项目还将使新的半胱氨酸启动底物被确定，使这一监管过程的全面影响在哺乳动物中得到赞赏。

This project aims to characterise and manipulate a novel oxygen sensing system, the cysteamine dioxygenases, to help understand how mammalian cells respond to low oxygen concentrations, a condition known as hypoxia. A number of the world’s most destructive diseases can impair oxygen delivery, altering biochemical landscapes. By understanding how cells respond to fluctuations in oxygen, the project expects to develop effective methods to treat these detrimental conditions. Characterisation of the cysteamine dioxygenases could establish a novel mechanism by which cells monitor changes in oxygen, assisting in understanding hypoxia and disease. The project will also enable new cysteine initiating substrates to be identified, allowing the full impact of this regulatory process to be appreciated in mammals.