Cysteamine dioxygenases: novel oxygen sensors implicated in hypoxia?

半胱胺双加氧酶：与缺氧有关的新型氧传感器？

• 批准号: DE190100668
• 负责人: Dr Mark White
• 金额: $ 29.26万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-05-27 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190100668
• 关键词: Cysteamine; dioxygenases; novel; oxygen; sensors

This project aims to characterise and manipulate a novel oxygen sensing system, the cysteamine dioxygenases, to help understand how mammalian cells respond to low oxygen concentrations, a condition known as hypoxia. A number of the world’s most destructive diseases can impair oxygen delivery, altering biochemical landscapes. By understanding how cells respond to fluctuations in oxygen, the project expects to develop effective methods to treat these detrimental conditions. Characterisation of the cysteamine dioxygenases could establish a novel mechanism by which cells monitor changes in oxygen, assisting in understanding hypoxia and disease. The project will also enable new cysteine initiating substrates to be identified, allowing the full impact of this regulatory process to be appreciated in mammals.

该项目旨在描述和操作一种新的氧气传感系统-半胱胺双加氧酶，以帮助了解哺乳动物细胞如何对低氧浓度做出反应，这种情况被称为缺氧。一些世界上最具破坏性的疾病会损害氧气的输送，改变生化环境。通过了解细胞对氧气波动的反应，该项目希望开发出有效的方法来治疗这些有害的条件。半胱胺双加氧酶的特征可以建立一种新的机制，细胞通过这种机制监测氧气的变化，帮助理解缺氧和疾病。该项目还将使新的半胱氨酸起始底物得以确定，从而使这一调控过程的全部影响在哺乳动物中得到认可。