Bio-compartmentalised chemistry: controlling selectivity using encapsulins

生物区室化化学：使用封装蛋白控制选择性

• 批准号: DE190100624
• 负责人: Dr Yu Heng Lau
• 金额: $ 29.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190100624
• 关键词: Bio; compartmentalised; chemistry; controlling; selectivity

This project aims to use Nature’s compartments (encapsulins) for use in synthetic chemistry. Controlling selectivity is a major challenge for synthetic chemists. In contrast, Nature has mastered the art of selectivity by using self-assembled compartments for important biochemical processes such as carbon fixation. The encapsulin-based platform technology resulting from this project will help address the problem of poor selectivity in synthetic chemistry, leading to more energy efficient chemical processes. Adoption of these processes by industry is expected to translate into significant benefits for the economy and the environment.

该项目旨在利用自然界的隔室（化合物）用于合成化学。控制选择性是合成化学家面临的主要挑战。相比之下，大自然已经掌握了选择性的艺术，通过使用自组装的隔间进行重要的生物化学过程，如碳固定。该项目产生的基于生物素的平台技术将有助于解决合成化学中选择性差的问题，从而实现更节能的化学过程。工业界采用这些工艺预计将为经济和环境带来重大惠益。