TOTALLY IMPLANTABLE ARTIFICIAL LUNG

介绍了一种完全植入式人工肺。 IAL是 设计用于完全支持需要长期（1- 月）人工具有治疗所需的交换支持， 复苏 IAL将为肺移植提供桥梁， 肺是不可能恢复的 IAL设计为完全灌注 右心室，而该装置被放置在平行于 天然肺（即，肺动脉至左心房）。 一个重要 与血管内氧合器相比，IAL的优势在于 IAL降低了右心室的阻抗。 在第一阶段，MC 3 试制了几种极低抗性、高效人工 肺，并与密歇根大学合作，成功地 在24小时绵羊实验中植入了10个装置。在第二阶段，IAL 设计将被修改，以匹配电阻和顺应性， 肺循环 将修改器械的几何结构， 预防血栓形成。 将使用定制挤出固体硅纤维 以防止等离子体泄漏。 计划进行广泛的台架测试，包括 流动可视化和溶血分析。 IAL将在 绵羊模型，目标是实现1个月的总气体交换 支持. 拟议的商业应用： 该设备的商业潜力是广泛的。 的数量 目前，美国肺移植候选人的潜在桥梁 超过1，000个，其中50%由于缺乏可用的 捐献的肺，感染性并发症，仅仅是因为他们不能 忍受手术，从而使他们的风险太高， 非常珍贵的器官。

A totally implantable artificial lung (IAL) is presented. The IAL is designed to fully support adult human patients who require long term (1- month) artificial has exchange support necessary for treatment and recovery. the IAL will provide a bridge to lung transplantation when lung recovery is impossible. The IAL is designed to be perfused entirely by the right ventricle while the device is placed in parallel with the native lung (i.e., pulmonary artery to left atrium). An important advantage of the IAL over intravascular oxygenators is that the advantage IAL reduces impedance seen by the right ventricle. In Phase I, MC3 prototyped several extremely low resistance, highly efficient artificial lungs, and in collaboration with the University of Michigan, successfully implanted ten devices in 24 -hour sheep experiments. In Phase II, and IAL design will be modified to match resistance and compliance of the pulmonary circulation. The geometry of the device will be modified to prevent thrombosis. Custom-extrusion solid silicone fibers will be used to prevent plasma leakage. Extensive bench testing is planned, including flow visualization and hemolysis analysis. The IAL will be tested in a sheep model, with he goal of achieving 1- month total gas exchange support. PROPOSED COMMERCIAL APPLICATIONS: The commercial potential for this device is extensive. The number of potential bridge to lung transplant candidates in the US is currently over 1,000 of which 50% ar rejected because of scarcity of available donor lungs, infectious complications, and simply because they cannot tolerate the surgical procedure, thereby making them too high a risk for very precious organs.