EFFECT CA++ FOODS ON BONE QUALITY IN PUBERTAL FEMALES

CA 食物对青春期女性骨骼质量的影响

• 批准号: 2750739
• 负责人: JOAN LAPPE
• 金额: $ 10.21万
• 依托单位: CREIGHTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2750739
• 关键词: adolescence (12-20); body physical activity; bone density; bone development; clinical research; densitometry; developmental nutrition; diet therapy; dietary calcium; disease /disorder prevention /control; female; human puberty; human subject; human therapy evaluation; longitudinal human study; middle childhood (6-11); nursing intervention; nutrient intake activity; nutrition related tag

DESCRIPTION (Adapted from the Investigator's Abstract): Osteoporosis is a major public health concern. The application focuses on the problem early in life. Since there are no known safe, effective methods for restoring lost bone to the osteoporotic skeleton, prevention of osteoporosis is crucial. If skeletal development can be maximized during growth, young people will begin adulthood with optimal bone quality and be less likely to develop osteoporosis in later years. Yet bone health of children has not been adequately addressed. This proposal will build on 3 previous studies of bone quality in children. The aim of this experimental study is to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in pubertal females at age nine. The hypothesis to be tested is: pubertal females who consume a high calcium diet will have a greater increase bone quality, as measured by densitometry and ultrasound, than pubertal females who consume their usual dietary calcium intake. A convenience sample of 60 nine year old females will be randomly assigned to a treatment group given high calcium foods supplying 1500 mg/day for 4 years or a control group consuming their usual dietary calcium intake. Measurements of bone quality, bone mass, physical activity, dietary intake, height, weight, Tanner Stage, and medical history will be made at baseline, every three months, and at the end of the study. Evidence of a positive effect of increased calcium intake from food sources on bone quality in pubertal females will be followed by another proposal to determine if this treatment cohort can maintain their skeletal advantage into late adolescence. The overall long-term aim of the P.I.'s work is to test interventions designed to bring about conscious increase in calcium intake and physical activity in children that will improve their bone health and help to develop lifelong bone healthy behaviors.

描述(改编自《调查者摘要》)：骨质疏松是一种 主要的公共卫生问题。应用程序很早就关注了这个问题 在生活中。由于目前还没有已知的安全、有效的修复方法 骨质疏松骨骼丢失，预防骨质疏松症 至关重要。如果骨骼发育可以在生长期间最大化，年轻的 人们在进入成年期时会有最佳的骨骼质量，而且不太可能 晚年患上骨质疏松症。然而，儿童的骨骼健康并没有 已经得到了充分的解决。这项建议将建立在之前的3项研究的基础上 儿童的骨骼质量。这项实验研究的目的是验证 膳食钙摄入量增加到1500 mg/d对增重的影响 青春期女性在9岁时的骨骼质量。假设是 测试结果是：食用高钙饮食的青春期女性会有一种 通过密度测量和超声波测量，更大程度地提高了骨骼质量， 而不是青春期女性，她们通常会摄入日常饮食中的钙。一个 方便抽样的60名9岁女性将被随机分配到 A组给予高钙食物，每天补充1500 mg，连续4年 或者是对照组，摄入他们通常饮食中的钙摄入量。 测量骨质量、骨量、体力活动、饮食摄入量、 身高、体重、晒黑阶段和病史将以基线为准， 每三个月，在研究结束时。积极的证据 食源性钙摄入量增加对大鼠骨骼质量的影响 青春期女性之后将提出另一项建议，以确定这是否 治疗队列可以保持他们的骨骼优势到很晚 青春期。S工作的总体长远目标是检验 旨在有意识地增加钙摄入量的干预措施 和儿童的身体活动，这将改善他们的骨骼健康和 有助于养成终身的骨骼健康行为。