FUNCTIONAL PARAMETERS OF AGING

老化的功能参数

• 批准号: 6098443
• 负责人: JOANNE S INGWALL
• 金额: --
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6098443
• 关键词: acidity /alkalinity; adenosine triphosphate; aging; animal old age; bioenergetics; cell differentiation; creatine kinase; glycolysis; heart function; heart metabolism; histopathology; juvenile animal; laboratory mouse; myocardial ischemia /hypoxia; myocardium; nuclear magnetic resonance spectroscopy; oxidative phosphorylation; oxygen consumption; perfusion

The fundamental premise underlying this proposal is that the normal program of differentiation in the adult mammalian myocardium changes in response to age and that these changes contribute to age-related differences in susceptibility to hypoxia and ischemia. Our major hypotheses are that the integration of the metabolic pathways for ATP synthesis and utilization changes during aging and, as a consequence, aged myocardium is more susceptible to acute hypoxic and ischemic injury. Corollary hypotheses are (1) that these changes are similar to those observed in chronic hypoxia and many forms of hypertrophy, (23) that decreased energy reserve (the CK system) contributes to increased susceptibility and (3) that changes in glycolytic capacity of the aged myocardium contribute to differences in pHi regulation during hypoxia.

这一建议的基本前提是， 成年哺乳动物心肌分化程序的变化， 这些变化有助于年龄相关的 对缺氧和缺血敏感性的差异。 我们的主要 假设是ATP代谢途径的整合 合成和利用在老化过程中发生变化，因此， 老年心肌更易发生急性缺氧缺血性损伤。 推论假设是：（1）这些变化与 在慢性缺氧和许多形式的肥大中观察到，（23）， 减少能量储备（CK系统）有助于增加 易感性;（3）糖酵解能力变化 心肌有助于缺氧期间pHi调节差异。