ANKYLOSING SPONDYLITIS RESEARCH--HLA B27 AND BEYOND

强直性脊柱炎研究——HLA B27 及其他

• 批准号: 2763878
• 负责人: JOEL D TAUROG
• 金额: $ 3.46万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2763878
• 关键词: disabling disease; histocompatibility antigens; immunogenetics; medical complication; meeting /conference /symposium; pathologic process; spondylitis; travel

DESCRIPTION (Taken from the application): Support is requested for a two day conference entitled "Ankylosing Spondylitis Research: HLA-B27 and Beyond," to be held on September 1 and 2, 1998, on the NIH campus in Bethesda. The purpose of this meeting is bring together a group of basic and clinical scientists from a variety of disciplines to critically evaluate ongoing research related to AS and to identify potential new avenues of research into the pathogenesis of this disorder. AS is a relatively common, chronic, painful, deforming, inflammatory rheumatic disease that affects the axial skeleton and, to a variable extent, other articular and nonarticular sites, with the onset at a median age of 23 years. Its pathogenesis is poorly understood, and current therapy inadequately prevents deformity and disability in many patients. In recent decades, investigation of AS has focused productively on clinical classification, epidemiology and genetics, and less productively on potential bacterial triggers. Relatively little investigation has been devoted to the cellular and molecular pathogenesis of the disease, particularly with regard to the chronic changes in the axial skeleton. The overall goal of this conference will be to galvanize AS research by providing constructive critical input for ongoing research and by attracting ideas and methodology from disciplines that could productively be applied to AS research but currently are not. Both approaches will take advantage of the attendance of NIH investigators. Four half day sessions are planned: (i) clinical, radiographic, and genetic aspects of AS; (ii) immunology and immunopathogenesis; (iii) bone, cartilage, and connective tissue; (iv) inflammatory bowel disease, bacteria, and mucosal immunology. Sessions 1 and 2 will consist predominantly of presentations by investigators currently engaged in AS research, and these sessions will be particularly valuable for gaining critical comments from basic immunologists and other investigators from NIH. Sessions 3 and 4 will consist predominantly of investigators working, respectively, on the molecular and cell biology of the extracellular matrix, and on the immunology and microbiology of the intestine and inflammatory bowel disease. These sessions will also benefit from the participation of NIH investigators. The format of the meeting is being organized to maximize discussion, to foster new collaborations, and to attract established and new investigators to work on problems related to AS.

描述（取自应用程序）：请求支持两个 为期一天的会议，题为“强直性脊柱炎研究：HLA-B27和 将于1998年9月1日和2日在美国国立卫生研究院校园举行， 贝塞斯达 这次会议的目的是召集一组基本的 和来自不同学科的临床科学家， 正在进行的研究有关AS，并确定潜在的新途径， 研究这种疾病的发病机制。 AS是一种相对常见的、慢性的、疼痛的、变形的、炎性的 影响中轴骨骼的风湿性疾病，在不同程度上， 其他关节和非关节部位，发病年龄中位数为23岁 年 其发病机制知之甚少，目前的治疗方法 不能充分预防许多患者的畸形和残疾。 近几 几十年来，AS的研究一直集中在临床上， 分类，流行病学和遗传学，以及生产力较低的 潜在的细菌触发器。 相对较少的调查 致力于疾病的细胞和分子发病机制， 特别是中轴骨的慢性变化。 的 本次会议的总体目标是通过以下方式激励AS研究： 为正在进行的研究提供建设性的关键投入，并吸引 从学科的想法和方法，可以有效地应用到 研究，但目前还没有。 这两种方法都将利用 NIH研究人员的出席。 计划举办四个半天的会议： (i)AS的临床、影像学和遗传学方面;（ii）免疫学和 免疫发病机制;（iii）骨、软骨和结缔组织;（iv） 炎症性肠病、细菌和粘膜免疫学。 会话1 2将主要由目前的研究人员介绍 从事AS研究，这些会议将是特别有价值的， 从基础免疫学家和其他研究者那里获得批评意见 来自NIH。 第3次和第4次会议将主要由调查员组成 分别从事分子生物学和细胞生物学的研究， 细胞外基质的免疫学和微生物学， 肠道和炎症性肠病。 这些会议也将有利于 来自NIH研究人员的参与。 会议的形式是 组织起来，最大限度地进行讨论，促进新的合作， 吸引现有和新的调查人员研究与AS相关的问题。